Singulair and headaches

When I was using Singulair I had trouble sleeping, then I had trouble waking, even after 10 hours of sleep! I had racing heart rates, headaches often, my blood pressure was high, which it never was before, gained weight, felt like I was often on the verge of tears, mean aggressive and plain old nasty which in unlike me. Would have the craziest dreams or nightmares I ever had. I've been off for several months (10) I've been like the old me for quite awhile now. I had surgery in 2006 and had the usual testing done everything was normal. I am getting ready to have some surgery so my dr. ordered some test, an ekg which came back abnormal, it was explained to me that it was like my heartbeats didn't have a strong beat, maybe a heart attack or something. I never felt or knew anything about this. I am wondering if the singulair did something to my heart. I was on singulair for about 18 months. If it weren't for the ekg I would have never known this problem exsisted. I have no symptoms of any heart problems. I am a 52 year old woman who eats great and exercises daily (since I was in my 20's) . Anybody else have any similar reactions?

I have an 8y.o. daughter that has been on Singulair for about 3 years now. Since she started taking singulair she has been absolutely miserable! She cries at everything, is very moody, has leg pains, wont leave my side and is tired ALL the time. She has circle under her eyes, she looks like she hasn't slept a wink in days! She has been off her Singulair for about 5 days now and she is a totally different person. She has been "happy-go-lucky" and full of herself, she has even woke up happy (which hasn't happened in I dont know how long). She was put on Singulair by our Doctor b/c she had Pnemonia two times in a row. She has Allergies and Asthma and for the past 3 years has been on: Singulair (4mg), albuterol, flovent, Zyrtec, and Flonase. That is just too much for a little girl to be on. She hardly eats at all, gets headaches. I just see such a difference when she is not on it but, what will she take in place of this? My husband also takes Singulair (he is miserable all the time), he doesnt sleep at night and is always tired. Anyone have alternative to this drug?

my 6yr old daughter was put on singulair at the age of 4 she had a reaction to nuts and had the allergy testing she was put on singulair and claritin and nasacort .(so she has been on the medication now for 14 months) about 3and 1/2 weeks ago she quit eating we had her to the dr several times they said it was all in her head that she could eat if she wanted to.she was then put in the hospital for 4 days they did the scope down the stomach found nothing i took her off all her meds because i didn't want her taking them with no food in her. she came home from the hospital and i put her back on the meds as the doctor requested and within 2 days she was crying non stop hitting me and telling me that she wanted to kill herself and everyone around her.she was putting her fists in everyines face and was very angry.she would cry and tell us that she didn't know why she was so angry.we took her back off of the meds because we were treating her for the stomach acid from not eating and within 4 days she was like a new kid.she is now eating ..happy ..and doing good in school..this is the 3rd time this yr on this med that she has quit eating we were told that it was all in her head .after reading everyones comments on here i called her doctor today and he said it could be the medication but they would have to put her back on it to check and i refused.no more singulair or clairitin for my children

i'm glad that i found this site...thank you.
I have a seven year old boy and a four year old girl that have both been on singulair for a couple of years. The first year their allergies weren't that bad, so i didn't really make sure that they took it daily...the past year, allergies have been worse, so i was making sure that they took it daily and that they didn't miss a dose. My son was in 1st grade last year and by the end of fall, he was going to the nurses office daily for headaches and stomachs. Where his drawings used to be of flowers and all of us as a family, they started being of monsters. We also noticed that his pupils were dilated more than normal (you could barely see any of the colored part of his eyes) and took him to an eye doctor just to find out that his eyes were fine and there was no medical reason for the dilation. I also asked the doctor and the school to test for ADD/ADHD, with them saying that he didn't have it..At night, both my son and daughter started waking up for no apparent reason (they had both slept through the night since they were about 1) and being very scared for no reason. The mood changes have been more noticeable in my son, but like most, i chalked it up to "a phase" and just part of being a boy....my daughter got clingier and moodier, but i know how it is to be a girl, so i just took it with a grain of salt. My kids have not been on Singulair for approx. a week now, and my son is back to the boy i knew....skipping through the house and yard, catching bugs to just look at them and not pull them apart and kill them, sleeping through the night, no trips to the nurses, and eyes that seem to be normal again...my daughter is actually a pleasant little girl that can't wait til she see's her brother instead of pinching, hitting, and trying to hurt her brother........Long story short, since they've been off of singulair, i have my kids back. my son had circles under his eyes at times and a runny nose at times and we have to find something to help my daughters allergies (she gets eczema and is borderline asthmatic) but we will deal with that and find something that works without harming them.....
Thanks again.

My Daughter has been the same way .. she had the headaches, stomach pain, very depressed .. she has missed 6 months of school she was afraid to go to school, shopping, and being left alone.. I have put her on medication for her depression, and anxiety . i have her in therapy for this... she is not the same child i just want my beautiful daughter back..We are having a hard time with her from school to he social life.. and from her tring to kill herself.. My daughter is only 13 years old...I think someone needs to pay for this... please there must be help out there...How long must this go on before people (FDA, Merck, ALA, etc.) will take this seriously?!?!?!?!
I want my beautiful katelynn back........................
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My 12 year old son started on Singulair 10 days ago. Yesterday, he threw up blood twice, so I took him to urgent care. He said it felt like someone was shoving knives into his stomach. He had blood tests and a CAT scan -- the connective tissue in his abdomen was inflamed and his lymph nodes are slightly enlarged. His white blood cell count is up slightly -- just above normal -- and his liver enzymes are elevated, which the doctor said is common with a viral infection. He has also had migraine-type headaches twice in the last week. HOWEVER: my 16 year old son has been on Singulair for four years, and it has been a lifesaver. He has had some hand tremors, which could also be aggravated by the decongestant he also takes, but no other side effects.

I'm an adult female with severe sinus polyps, adult onset asthma and allergies. Initially Singular seemed to be helping my nasal polyps, when nothing else helped in any way. I made several attempts to use Singular, and proved repeatedly that this medication did, in fact, cause me severe side effects - even when I used a childs dosage. While using an adult rx for Singular, I immediately began experiencing horrific nightmares (which I have never had in my entire life). I also had extreme knife like pains in both ears, which made me feel like I had a severe ear infection, chest pains where it felt like a cinder block was lying on my chest, and migraine like headaches (which I've never had). I stopped the medication after about a week and the nightmares went completely away, but it took me a couple weeks to recover completely because I developed what felt like a respiratory infection and ear infection as soon as I stopped using it. Because Singular seemed to slightly reduce my nasal polyps on my first attempt, my allergist suggested I try using it again - almost a year later. When I first began, I completely forgot about the negative side effect and why I stopped using it in the first place, and just gave it another try. I again experienced the same horrific nightmares, ear pains, but this time got a strange rash/cluster of blisters under both eyelids which my eye doctor confirmed was an allergic reaction to something I was using. Singular was the only medication I had changed. My allergist thought I should give it longer to see if the symptoms went away (because they probably weren't caused by this medication - and were due to something else ???). Fearing going to sleep, I decided to try taking the medication in the morning instead of night, and had my physician reduce my rx to a childs dosage (5mg). The nightmares lessened, and the blisters under my eyelids went down, so I continued using Singular for about a years time. What I didn't realize, was that over this time I was becoming depressed, fatigued, and became easily agitated and short-tempered, which was very different since I was normally a very happy, energetic mom. My nasal breathing seemed to be slightly improved, so I just kept taking the medication - not realizing that it was causing all of the other problems I was experiencing. I became so fatigued and depressed feeling, that all I wanted to do after I got my kids off to school was to sleep until it was time to pick them up in the afternoon. I was also experiencing stomach pains for unknown reasons. I was certainly not myself. I didn't realize that while I was using Singular I had lost complete interest in everything that I normally loved in my life. And please note I'm 45 years old, and I was using a childs dosage. ( I can only imagine what this medication does to a child. )Fortunately for me, I accidentally forgot to refill my prescription for a few days and noticed that my depression started to improve. I decided not to refill my rx and stay off it to see if I continued to improve - and I have. Unfortunately, even though my depression has all but gone away, I'm experiencing symptoms which must be from withdrawal of the medication - and they are just as scary as the side effects were. Now that I'm not taking Singulair any more (and I've made no other medication changes), I have extreme fatigue beyond belief, and ache everywhere. My muscles are in such pain that I'm having difficulty doing things I would normally do. I have extreme weakness in both arms and legs, and my back aches almost constantly. And strangly enough, my asthma and allergies have slightly improved since stopping Singular - I thought for sure my allergies/asthma would worsen when I stopped completely - but they did not. All I can say is - please trust what your body is telling you - even if your physician tells you otherwise, and do not use this medication or any other if you experience adverse side effects to it. I would never give this medication to a child that wasn't old enough to tell me what he/she was experiencing, and would document the childs temperament, ailments if any, and what changed once the medication was started - and discontinue it immediately if even one adverse side effects occurred. One last note - I am still experiencing vision problems, which I feel are due to using this medication. Hopefully, no other permanent damage to my body will result from the Singular that I've already used - and I hope you Singular users will recover completely too from its dangerous side effects. Wishing you the best of health!

My son has been on singulair for the past 6 to 8 months and my husband and i have had a very difficult time with him and his behavior. We have noticed him being very angry, mad, sad, screaming out for no reason, very defiant and not listening. He has been making threats to me for a while now, saying he wants to kill me, but only to me, his mother. He has become physically violent to himself and household items and me at times. He has night terrors and screams out at least 6 nights out of the week. He has bad headaches and often doesn't feel good. His stomach bothers him a lot. He makes constant threats to me and seems to not be able o handle the simplest task. I will not be giving my son this medication ever again after reading on this site. My son has suffered long enough as have we, his family. I want my loving sweet baby boy back! It makes me wonder what the hell is wrong with our society that they would continue to prescribe this medication knowing the horrible affects that our children endure. Shame on you! You deserve more than a slap on the hand! You should have your licensed stripped and e put out of business!

I find it very interesting about the possible link between Singulair and visual disturbances. My daughter had been told (about one year after being on Singulair) that she had damage to a nerve in one eye. She had never received any type of head trauma and the Doctor could not figure out how this happened. He told us that eventually her headaches would get so bad that she would have to have her eye removed while they tried to repair the nerve, and then they would replace her eye. I would be interested to hear if there are any other stories similar to this.

My 6 y/o daughter has been taking Singular for approx. 2 years. She began to have regular stomach pains shortly there after. She was sent to Children's hospital where they put her on a laxitive which made things worse. Then we began testing for food allergies only to find out that she tested positive for a 3 page list of foods. We eliminated those food and had her tested again. She was subsequently allergic to the foods we eliminated. She was recently down to rice, a few meats and some vegetables. Guess what, she is now allergic to those foods.

All this time she has been complaining of severe leg pain, eye pain, throat pain, numbness and tingling in her hands a feet, all of which come an go. I have reported this to all the doctors and specialists we have seen. She had undergone countless blood tests to rule out autoimmune disorders and all come up negative.

She began to develop severe anxiety and just had the blues most of the time. She would be crying and saying off the wall things like, "I don't think my fish is happy". She couldn't stand to be away from me and would stress out about even weather or not she would sit by me at a restaurant. I mentioned this to all of the doctors. They said to not make too much of it. One suggested she see a psychologist. NOT ONE DOCTOR EVER LOOKED AT THE SINGULAR.

Finally about 4 weeks ago my neighbor who is a scientist at a pharmaceutical company called me and told me about the "black box" warning that had just come out on Singular. I took both of my children off of it immediately. My daughter went through about a 10 day period where her anxiety got worse and then it was just gone. We are adding foods back into her diet and at this point she has not had any severe allergic reactions.

The last 2 years have been a complete nightmare for her and for us. I am a medical professional and I have had doctors treat me like a hypocondriac, hypersensitive, attention seeking mother. I feel so justified and saddened by the recent findings all at the same time. Most of all I am so grateful that we figured this out before things go even worse.

Please let me know if anyone else is suffering food related reactions as a side effect.

I wish I would have read the side effects before trying this med on my 4 year old. I've been receiving complaints from his preschool teachers in the last few weeks about him throwing things, hitting kids and adults, yelling, spitting, name calling and the length of time it takes him to calm down. He can't tell me why he is doing these things but can give me a detailed account of all he is doing and to whom and admits its wrong. I've ignored the messages he's sent me saying his stomach hurts even to the point of crying about it 1 day, complaining of headaches that he is sleepy at home and school no matter how early he goes to bed or how late he wakes, a little vomitting, eye swelling occasionally, stuffy nose, thirst leading to increased accidental bed wetting and all this has been going on since he started the med in late July. I even took him to a child psych who said he couldn't find any reason he would act out and that he is well spoken, mannared, entertaining and knowledgeable for his age. Starting today he will never take this med again! The doctor says give him 5 days for the med to be out of his system. I hope this is the problem and feel terrible for putting him, his classmates, and teachers through this.

I have been reading all of these posts and have another question. I hope that someone can help. My daughter, 8 years old, has been on Singulair since she was 4. She is normally a very happy girl with a wonderful disposition. For the last year or so, she has been having trouble getting herself to sleep at night. She says that she hears things in her head such as ringing or "noises". A few hours before she knows it's bedtime, she cries and when we ask her why she's crying, she can't give us a reason. We initially thought that she was crying for no reason because she didn't want to go to sleep. I remember reading about the side effects of Singulair causing mood swings, etc., but her's are not violent mood swings. Just very emotional and has a hard time coming down from the "episode". I'm at a loss...I have not talked to her doctor yet about it, but have told her that we will make an appointment this week to discuss it with him. My husband suggested that maybe it sounded like she was having a panic attack or anxiety attack. I hate to label her as that at such a young age. My mind now goes back to the side effects of Singulair and maybe this is to blame. Any help or suggestions would be greatly appreciated. Thank you! Concerned Mom

I'm a 45 yr old female, I've been on Singular for many years (originally for allergies and then asthma too) and have quit three times due to "possible" side effects and tried other asthma medicines. Inhalers make my GERD worse and I'm anxious all the time. I have to say Singular is the only thing that really works for my asthma and I keep going back to it because it does work. Also, I found that when I quit and expected my depression, headaches or fibromyalgia to go away they didn't... so I own these symptoms now regardless of Singular. I've always had mild depression and anxiety and all the prescription drugs for this I find are really too strong and are made worse then by Singular. For mild depression I find taking SAMe and St. John's Wort to really help me. Can't say if it would help others but you might look into it. I think it's important that doctors understand a link with depression and Singular but for some of us there's not another choice.

My son suffered from pneumonia at age 6 months till age 2. They had him on Flovent and Singulair from the age of 1. For as long as we can remember, he has been an aggressive, mean, bitter, angry child. The slightest thing would set him off. The doctors had just had him tested for tumors and cancers and other serious head related problems because he was constantly complaining of headaches. All tests came back normal. Then we heard that Singulair can cause ADD amongst many other side effects, including headaches. We took him off of Singulair and after only 2 days off of it he was a completely different little boy. He is happy and loving, calm and patient. He isn't dissolving in a fit of rage at the simplest thing. We can not believe the difference in how he is acting.
We found about 2 years ago a natural supplement that has really helped control his and my asthma and allergies. It is called OPC-3. It is an incredible anti oxidant that helps with so many health problems! If you would like more info, just let me know. It has been a life saver for our family and many others! Here is a website where it can be found.
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It is under the health and nutrition tab on the left side.
Good Luck!!

My 10 year old son has taken Singulair on and off since he was 5 years old and has been on it for the past 3.5 years. My son at an early age was affected by a bad marriage and then the divorce when he was 5 yrs old. So we always suspected that his behavior issues were caused by this and I had done everything I possibly could to give them the help he needed to get over and through his issues. He was held back his first year of Kindergarden and during his second year midstream he was placed in a special class for behavioral problem children. Nothing ever seemed to help him, everytime we would see some progress and encouragement we were always blind sighted by a behavior that was always worse. Two steps forward and them 5 steps backwards. I always knew that his problems would never get better overnight so I just kept on going. He was diagnosed with ADHD but because he has some ticking issues I had to put him on Strattera which was did not do a thing for him. I always described him as my Dr. Jeckyll/ Mr. Hyde child. He could be really good and sit still and behave but I think he had to try really hard to do so. He eventually was always overpower by the impulse to show negative behaviors. Defiant, extremely impulsive, always negative and completely miserable all the time. He also went through phases of compulsions. There was always a compulsion of the month- germs, bathroom habits, noises, repetitive words. He hated school and always complained of a stomach ache which i thought he was always faking to get out of school. He had confrontations in school everyday for most of the day. I often thought some of this was because of being tired all the time. We had battled over bedtime every single night. He was terrified to go to bed alone, I tried everything to get him to sleep alone. I wore myself out falling asleep next to him, I would then go to my own bed only to be up with him half the night going back and forth. I gave in many a night and slept with him just so we could get a good nights sleep. At age 8.5 I finally got him to go to sleep alone but the lights haf to be on and he has to know that I am still awake before he will fall asleep. He would always say he didn't want to go to sleep because when he does he has bad thoughts about me and people that he loves. He always had an extremely hard time excepting the word "no"- he would flip out and hit his head with whatever was handy, throw things, break things, scream holler etc. It would take hours to get over it. When he did he would be very remorseful and lovable. He was always in turmoil. Finally in February of this year, this graduated to a new level where he would want to just kill himself and would actually go and pull a knife out of the drawer and just shake with anger as he held the knife to his throat. I was terrified although i really didn't think he was going to harm himself he just wanted to scare me. Then at the end of March when i first heard the news about the possible side effects of Singulair, I had only heard about the suicide effect. Oh great just what I needed was this medicine causing him to do that. The doctor was thinking about taking him off if this summer because he wanted to see if he out grew his seasonal allergies so I took him off immediately. Well I had no idea about the other side effects until my son turned into a completely different kid. School noticed a huge difference in him! His grades went up, his is able to control his behavior, he is happy he is NORMAL. I never suspected this drug as the culprit due to the timing of taking it. Our lives have changed completely. When i first found this site, it seemed as though some of the parents were writing about my child. It is amazing. My son still has some old habits to break but overall he is a wonderful and normal 10 year old boy. He did not outgrow his seasonal allergies but Allegra seems to help in through it. I get so angry- his whole early childhood was ruined by this medicine. He is a labled kid in our school system. This whole experience has opened up my eyes. Thank you for letting me share my story.

I am finally writing after reading these posts since the end of April. That is when I took my 11 year old son off singulair, in an act of desperation. He has been on singulair on and off for about five years for seasonal allergies. He started again in mid-March so it could get into his system, before the allergies started. Immediately thereafter his behavior changed. He was arguing on a daily basis. He would hit, kick or trip me when he was angry. He was starting to destroy things in anger. He seemed to be fueled by anger. It was affecting the whole family. He was starting fights with his younger brother, my husband's heart was palpitating and I was crying every day. I heard about Singulair side effects and looked it up. I saw that it caused behavioral changes and out of desperation, took him off, not knowing what to expect. We had three days of total peace, then on the fourth day another outburst. Then my son told me he had taken a singulair the night before. That was it. I threw every pill in the garbage. He no longers acts like that. It's been almost two months so I am convinced it was the Singulair. By the way, he always complained of headaches, stomach aches and would scream in his sleep. Who knew - it was the singulair all along.

Is heart racing one of the side effects? I have problems with edema which are worsened by Singulair and Zyrtec. Vivid Night terrors depression, anxiety are standard also made worse. Headaches extremely high blood pressure and nausea. I have been off the singulair for a month. I am Zyrtec Free as well.
I too will rely on my inhalers. This drug should not ever be prescribed for children.

My 9 year old son only took Singuliar for about 5 weeks. He had side effects almost immediately, he was so aggressive, angry all the time, headaches, stomach ache and feeling like he was going to throw up, bad nightmares, a horrible rash, biting his nails, not focusing in school and got into trouble all the time, no appetite but his little body seem puffy all over. He has been off this medication for 3 months and he is still not 100%. He cries at little things and still has the same rash and with meds it is not going away. He had to change schools as he still was having problems in school. He just seems like he is not the same little boy and something is just not right. I do not know what to do at this point. Doctors say it should be out of his system by now, but if it is than there is permanent damage to his brain as he is just not the sharp little guy he was. We have had to take him out of all sports. Anyone else having these same problems???

I have posted a few times. My daughter started taking singulair 11-17-2003 and I stopped it 3-28-2008. She is the one that dropped out of dance and cheerleading, withdrew from old friends and family, headaches, stomachaches, missing school with this, depressed, anxiety attacks and CUTTING her self under her clothes. 6 months with a psychiatrist did not help. She is now about 80% back from the darkness. She is so much better and is such a loving child, She is not cutting, has a part time job, and has passed all her classes with 3 A's, 1 B, and 2 C's. BUT there are learned behaviors while in the darkness that still show up. Not every day but they are there. She has been pushed off her life path. I am hanging on to her with all my might and I know that I will get her through college and she will have the tools to be self reliant and happy BUT what could she have been if I never gave her singulair???? I can not help but feel guilty to what I have done to this child

I am so glad I found this web site I just wish I had found it BEFORE I took my Singulair this evening. I am a 54 year old mother of 12 year old twin boys and I only just begun taking Singulair 9 days ago for lingering asthma problems I could not shake. My difficulties with Singulair started right away with headaches (though I didn't realize what was going on till I found this site) and by day three I was starting to have the dreadful nightmares that everyone is describing. Now it is also obvious that an extreme depression has settled over me and seems to be getting worse every day. I feel like I am living in the shell of myself and almost as a third party observe the awful way I have been treating my family. It makes me feel so miserable all I want to do is to be by myself, shut down and sleep. I read in the other letters about body/back aches but not about what I have been experiencing. Just a few days ago - terrible leg pains/cramps began pulsate along the back of my upper legs and sometimes the lower back. I am stiff and uncomfortable during the day but at night it is terrible. Each night it has gotten worse. The pain in my legs is nearly unbearable even as I write this and is what propelled me to get back out of bed at midnight and to the computer and to this site. Thank goodness and thank everyone who has written - it is obvious you have saved me much pain and grief - hopefully my letter will help someone else. But for right now this six month supply of Singulair is going in the trash immediately!
Lauri

Wow, I just found this site. The child that had strep especially caught my attention. My daughter, 11, has been diagnosed with PANDAS, which is also a controversial diagnosis. I'm not sure when she went on Singular, but it was a couple of years ago due to allergies. She had bad reactions to anti-histamines. For the past two years we have been dealing with just about every issue posted here. Physical pains, stomach, headaches, joints. urination issues, high cholesterol, but the worst have been the irritability , mood issues, OCD, fears of cutting herself, bad thoughts, suicidal ideation. She was on Zoloft which made things worse, She was hospitalized at her own request. She was placed on Prozac. She's had years of therapy. She would say life is just so hard and she wants to be a normal kid. About a month ago her pediatrician mentioned that there were some reports about Singular and it would be something to watch for and discuss with the psychiatrist, He didn't seem to know much about it. Last week after another suicidal ideation I decided to research the singular issue. I had been attributing everything to the PANDAs. I was so surprised to see the similarities. I took her off of it Friday and have seen some changes already. I hope we see that continued improvement. Thanks to all who have shared stories, it's so helpful. To have hope that you'll get your kid back is great.

My daughter was on Singulair for about 4 weeks this spring. She went from an outgoing talkative 15 yr old to being withdrawn and sad. Her symptoms were feeling hopeless, headaches, stomach pain, constantly tired. She was sleeping 9-10 hours at night without feeling like she had slept at all. She would fall asleep in class (not her normal at all). Her teachers noticed that she had stopped participating in class and seemed "sad". I took her to her pediatrician and she ordered blood work and an ultrasound of the abdomen-all of which came back normal. I toyed with the idea that maybe she was becoming clinically depressed. I researched her symptoms and came across others who had similar symptoms while on Singulair. I took her off Singulair and have noticed an improvement in her mood. Her teacher commented yesterday that it was nice to see her smile again and being happy. She told her that she noticed that she had seemed "sad" these last few weeks. I hope that they take seriously these potential problems with this drug. I will never allow my daughter to take this or any other related drug.

Hats off to Dr. Engler. Patients need this type of support. He is a unique individual willing to tell his own experiences.

Singulair increases risk of Suicide? Don't just poo-poo the possibility

This analysis is solely the work of the author. It has not been edited or endorsed by GLG
.
Analysis By:David Engler, MD
Physician, The Allergy Clinic

Implications: It is difficult to imagine why taking Singulair would increase the risk that someone would complete suicide. After all, what does a leukotriene receptor antagonist have to do with mental health? I don't know. But doctors, ask yourself, have you ever had a Singulair patient stop taking it because it caused headaches? I have had dozens of them stop taking it because of headaches. When they attempt to try it again, the headache comes back. But the package insert says that the risk of headache is no greater than it is in people who took placebo. Try explaining that to the patient who got the headache--it's very real to them.

Analysis: The story about Singulair and suicide may be based on some cause-effect relationship. I don't know what that is, but I will tell you story of a patient I saw last week. She is a 19 year old college student, with the usual stresses of college. I have been treating her for asthma and allergies since she was 10 years old, and she had been on Singulair for about 5 years.

She was treated in the town's ER for an intentional Tylenol overdose; she took 15 of them for a headache that wouldn't go away. The usual charcoal to the stomach, with Mucomyst to protect the liver from the Tylenol went fine. While under evaluation, the ER doc also noticed she had been "cutting" her wrists and arms. She said that it relieved stress.

They asked her about the Singulair and she said it gave her bad dreams. Astutely, they stopped it. All this happened a week or so before the recent news headlines.

Is that cause and effect? No way....but remember that MRK is the same company that still denies that Vioxx can increase the risk of heart attack. Oh yeah, Vioxx. That drug would have been great as a niche drug if given to treat pain in those already at risk of a GI bleed. But, no, MRK was encouraging dentists to give it out for toothaches, and most patients in my practice who were on it had no history of GI bleed. MRK wanted Vioxx to be a billion-dollar blockbuster; had it been marketed appropriately, it may still be on the market.

So how will I change my prescribing habits? For patients who have a psychiatric history, including those who take antidepressants, I'll mention the story of this patient to those on Singulair and start asking questions to try to determine if they are brittle or fragile from a psychiatric standpoint.

This may be much ado about nothing, but what if it's not? I've learned to stop drinking the drug company Kool Aid without a few grains of salt.

Thank you so much concerned citizen for the article on singulair by David Engler MD. He is describing what my 16 year old daughter has been going through. Headaches, CUTTING, stress etc.... We all know. Thank you, Thank you. By the way she keeps improving. Yesterday, she said "I love you" first. Sue

My son, Wilson, is a bright, easy-going, athletic 12 year old who has a history of asthma and allergies. After several asthmatic episodes from age one year to about four, he was prescribed Singulair. The asthma triggers seemed to be change of season or congestion from a cold, but not from exercise or physical exertion. As I recall, his asthmatic episodes seemed to decrease after he was on 5-10 mg of Singulair, and even more so with each passing year. Over the years, of my three sons, Wilson was the one to catch any virus that came around and missed more school time than both of his brothers combined. Often, he was the only one to get sick from a virus, which never passed to anyone else in the family.
About five years ago, Wilson started complaining of stomach aches. He was tested and was prescribed Prevacid on and off since then with varying success. In the last couple of years, headaches would come and go. He was re-tested for allergies and blood work with no conclusive results. About 2-3 years ago he would complain that he “felt funny…like he needed to do something.” Further conversations revealed that he was expressing anxiety. He’s a good student, has lots of friends at school, and is popular among his sports team mates. Occasionally, a teacher here and there over the last couple of years would note that he did not participate enough in class, or did not appear to be attentive. We thought perhaps he is shy. Still his good behavior, agreeable personality and diligence otherwise earned him good grades overall. He loves school and was very unhappy having to stay home when he was sick.
This past winter, he seemed to catch a virus about once every month and a half which caused him to miss 2-3 days of school. Headaches and stomach aches were common with each illness (sometimes nausea), and sometimes these same symptoms when he was not ill. He would only complain when they were prolonged or significant. Trips to the doctor did not result in anything conclusive. Again, Wilson was only too happy once he returned to school.
He claims that sometimes in school he feels like he’s in a fog and has difficulty concentrating. He gets plenty of sleep and sometimes sleeps up to ten hours during the weekend. We attributed it to adolescence and a busy schedule. He claims that this year is the easiest for him at school, and his social life with his friends is very active. His friends’ parents like him and find him to be an agreeable child. Other adults mistake his sometime mumbling answers and lack of eye contact rude. We concluded that he is just shy. He is the most hyper of his brothers, and has difficulty sitting still and constantly exclaims that he’s bored. We chalked it up to being an active boy. His grades are good in school and we never get complaints about bad behavior.
The last illness started a week ago, and he’s still out of school. The doctor said he had no significant allergy symptoms, other bacterial infections, and his blood work all returned with normal results for white blood counts, liver and kidney functioning and anemia. He can’t return to school because of his constant headaches (which cause pain in different parts of his head), nausea, constant stomach aches, no matter what he eats, and feelings of anxiety, mostly in the evening hours. He’s also complaining of dizziness, leg cramps and other muscle soreness. The notable difference in this illness is the anxiety. My husband and I take turns staying home with him, but if we left him alone for a half an hour at a time while the other was in route picking up a sibling, he became very anxious. In the past, he seemed to enjoy some alone time at home so he could play his computer games. He also becomes easily dizzy with shooting pains in his muscles. The doctor said that viruses can manifest themselves in later stages in the form of sore muscles. However, he was concerned about Wilson’s feelings of anxiety. The anxiety had not been as prevalent in prior illnesses. I finally signed onto the internet reading all the stories about other parent’s observations of their children on Singulair. My husband cautioned me about “internet diagnosing” with symptoms and stories that can be easily taken out of context in hope of self-diagnosis. I’ve always thought that Wilson’s doctors have had good judgment. Both my primary physician and allergist don’t think that Singulair has caused these symptoms, but agreed to take him off as long as we monitored any effect on his asthma.
I don’t know what to think. I want the cause of these problems to be the Singulair, because it’s an easy answer. Today will be the first day he’s off the medication. He probably won’t go to school again tomorrow. We’ll wait and see what happens…

I took my 16 year old child off of singulair 6 weeks ago (3-28-2008). She started taking it 11-17-2003. She became dark, depressed, grades dropped, dropped out of dance and cheerleading, started cutting her legs with razors, stomachaches, headaches, anxiety attacks, trips to the emergency room. 6 months of fluoxetine given by her psychiatrist. Nothing helped her be happy again. Sad and Dark young woman. NOW: She smiles a lot, and is eating diner with the family. No headache or stomachache for a month now. She is sleeping better. Before she said that her mind would not stop thinking. She is taking pictures again and even asked me to order her book called "Understanding Exposure" and is talking about taking a class on digital photography at NMSU branch university to start on her college electives now. She is out more and even has a part time job at an ice cream parlor. Just lately I have stopped checking the trash for waded up tissues with blood (from cutting). Chris, I have had all her medical records sent to her primary Doctor and we are very willing to open them up. You have to have a child suffering to understand where we are coming from. The most dangerous place on earth is standing between a mother and her child. Singulair took our children from us and maybe changed them in some way forever.

Our son was put on Singular almost 2 years ago to help with his "moderate" asthma. It has been the hardest 2 years for our family. My son who was already very senstive became very depressed. He showed no interest in anything. He was always sad and very down on himself. He had awful night terrors/nightmares. He didn't want to go to school or do anything. We continued to sign him up for sports/piano/scouts and it was a battle to get him to go. He always had headaches, which I thought were because of dehydration and made him drink water. We had him seeing a therapist trying to help him with the sleeping problems and the depression. We switched his room with his sister to physically make him closer to us at night. He was anxious and very irritable. If something went wrong, he couldn't handle it and had complete meltdowns. If he didn't eat anything for a while and his blood sugar got low, he was uncontrollable. To add to the problem was he was never hungry so I would have to force him to eat something about every 2-3 hours to prevent the meltdown.

The good news is that he has been off of Singular for over a month now and he is a new kid. He is excited to go to practice and will ask his dad to play catch with him in the yard. He is happier and we have not heard once "this is the worst day ever" which we had heard all the time before. He has not had one headache and seems to have a little bit of his appetite back. He is happy and holding his head high. Now, he still doesn't want to go to school (what 8 year old boy does), but he doesn't fight me when I tell him it is time to go. He does not have the meltdowns or the irritability. He even showed some empathy to my husband last week.

My husband and I are amazed at how different he is. We are also very upset that for almost 2 years we made his life miserable by forcing him to take this drug. I think for kids that are already sensitive to things it heightens everything! I am filing a complaint with the FDA and spreading the news to all my family and friends. I hope this information helps! I know I have learned a lot from reading these posts.

I spent the weekend reading about the development of Singulair. The early studies recognized that the first phase of the acute asthma response bronco-constriction was probably not caused by leukotrienes. They identified histamines and prostaglandins as the probable sources. I don't think that changed because the Singulair literature states that it should not be considered as a treatment for that. Leukotrienes were a source of inflammation caused by eosinophils and mast cells present in greater numbers (than normal) in airway tissue. So, it was beneficial to find a way to decrease that.

The cysLT1 receptor was identified as source of the signals that tell the cells to produce leukotriene. The receptor, a gene, consist of 337 (they think) amino acids. They modified a compound that would bind to that receptor thus blocking the cells ability to produce leukotrienes. This compound is very specific. It was formulated to bind to the "model" receptor. This compound will not even bind to cysLT receptor sub-types. (That is the good thing.) There is an enormous amount of research that discusses the genetic variability of the chemical reactions that occur in the leukotriene (calling it this for simplicity) pathway. We are also seeing that a number of researchers would like to use gene profiles to predict whether patients will respond favorably to different asthma/allergy drugs. ALL PATIENTS HAVE A RIGHT TO KNOW IF IT IS INHERENT THAT SOME PEOPLE WILL NOT RESPOND TO SINGULAIR OR RESPOND ADVERSELY.

There are many studies from the 1998 era that conclude that montelukast is not effective for everyone. Those researchers stated that it can be predicted that those people who are going to respond favorably will do that within the first 14 days or so. That conclusion would be consistent with a genetic component for efficacy and safety of Singulair. Those doctors concluded that those who did not respond within that time frame should not take Singulair for fear of harming them. That makes good sense.

The Italian researchers wanted to know if there was more going on than blocking leukotrienes in the action of montelukast. They set up a "test tube" study regarding montelukast, the cysLT1 receptor, and some t-cells that they selected. Why? Researchers always have something on their minds. They observed the death of these particular t-cells.

Montelukast is a quinoline. We basically know of quinilines and quinolones as compounds that were invented as broad spectrum antibiotics. They work because they interference with bacterial DNA so they cannot replicate themselves. Montelukast is a quinoline modified to bind with the cysLT1 receptor (a gene) and prevent that gene from activating. That's consistent with what a quinoline/quinolone does.

So what does montelukast do in blood plasma if it does not bind to the receptor because of genetic mis-match? (If montelukast does bind, then a chemical reaction has occurred and the liver will break down the by-products. Montelukast metabolized in 10-12 hours.) What happens if it doesn't bind? How long before it breaks down? Does it produce toxic by-products?

I want to know what happens to lymphocytes such as t-cells just because montelukast is a quinoline. Maybe nothing but what's up with the Italians researchers? I want to know if montelukast has the capability to interfere with lymphocytes who can clone themselves. That could be a good thing under circumstances when these lymphocytes are causing inflammation. But it could be a bad thing in the case of normal individuals with no problems.

I want to know if the bad side effects are due to the fact that the body has to break down and metabolize a quinoline that did not bind to the receptor for which it was created. The side effects of Singulair are strangely similar to what is observed in the quinolones such as levaquin. I have not as yet been able to compare montelukast as a quinoline to levaquin as a quinolone. I am hoping to find something on these categories. There may be no reason to worry that they cause similar damage. But frankly, I think that there is. There is some terrible chit happening to some people. The scariest is the neurological damage.

All of these questions would be in the everybody pharma knows to ask category. I don't know where the answers are. I haven't found them as of yet. Maybe there are no answers. We have to remember that Singulair and Vioxx were released in the same year. They have continued to be drugs under the current executive management of Merck. If the Vioxx marketing promoters had their ghost writers, why not the Singulair marketing promoters. The genetic component appears to be widely accepted but we haven't heard one thing about even that.

I think that it is sad that maybe the marketing of Singulair as one stop shopping for asthma/allergies may have destroyed the original concept. I really think from reading the original work that they knew that they couldn't engineer a drug for one size fits all. Everybody gets harmed when information is withheld.

Shame on the allergist who yelled at the mother who wanted to discuss issues. Does he know exactly who is allergic to Singulair and who isn't? Get him a dunce hat. Just because Singulair is marketed for allergies does not mean that you cannot be allergic to it. See the power of Madison Avenue? The ad agencies focus group these drugs to death. The ad agencies cleverly craft the product information. A good piece of legislation would be to prohibit consumer drugs ads.

I usually have allergy headaches in the morning which would go away after taking 1 Benadryl w/ Tylenol. About a week ago my doctor started me on Singulair because she was concerned about me taking Tylenol daily. The last few days I've had terrible headaches that linger most of the day. (I've continued to take the Benadryl w/ Tylenol to try to help the headaches, but it's just not working.) Today is day 7 with the Singulair, and the headaches seem to be getting worse. Are headaches common with Singulair?

I have communicated directly with Leslie Hendeles, a leading professor of pharmacology and pediatrics at the University of Florida who's direct quote to me was:
"In response to your last comment, I thing Singulair has modest efficacy, and if we take all of our patients off this drug, THEY WON'T SUFFER. This is NOT an important drug for pediatric asthma, as are inhaled corticosteroids."

Ironically, this is the same individual who was quoted in an ABC news article as saying:
"We have hundreds of children on Singulair and have never heard parents make complaints about psychiatric side effects. Moreover, there is no mechanism for this reaction … We will be telling our patients not to worry about this."

WAKE UP EVERYONE...THIS IS AN ADMITTEDLY OVERPRESECRIBED DRUG THAT HAS WORKED WELL FOR MANY, BUT HAS ALSO RUINED MANY LIVES.

The manner in which this drug is casually overprescribed by so many doctors is freakish. I firmly believe that this drug has caused countless misdiagnoses such as ADHD, Bipolar disorder and others. IT FUELS A GOOD PART OF THE ECONOMY TO PUT SO MANY PEOPLE ON THESE DRUGS. I BELIEVE THE PHARM INDUSTRY IS VERY CALCULATED IN THIS MANNER.

Question what your doctors tell you.
See my other posts under matthewct1. I dealt with a situation where my 5 yr. old son was on the road to being diagnosed with ADHD which couldn't have been further from the truth. Singulair changed him. Since he's been off Singulair everyone (teachers, pediatrician, family, etc.) unanimously agree that he does not show the ADHD symptoms like he did on Singulair.

Hello to everyone, I just came home from a parent teacher conference for my son who is 7 yrs. old, and heard the same old thing, "he is restless, impulsive and has a short attention span". He has been taking Singulair for about 3 yrs.. Since he has started school I have had these complaints and have also been told he displays symptoms of ADHD, which ironically has been for the last 3 years. Like any parent, I question" if I am doing something wrong with my parenting, is his diet good, etc. etc.", I am also a nurse, I realize that medications are needed and beneficial in some circumstances, however I firmly believe and was taught in nursing school that medication is last resort. That being said, I have been very adament about NOT giving my son ADHD medication after doing alot of research on the different meds and their side effects. So, we started him on all natural vitamins, changed his diet some ( kids got to have candy once in a while) and started a more structured routine( the best we can since we both work) and also enrolled him in Sylvan. The teacher says there is a 50% improvement but he is still impulsive and still does not pay attention like he "COULD", again suggesting he needs ADHD meds. I came home in tears and started to do more research online to see what else can I do besides putting him on psych meds?....Then I came accross this site, I just want to cry after reading all these posts. I wonder, could this be his problem, the Singulair?.. About a year ago he use to get up in the middle of the night, 5 out of 7 complaining of nightmares, hearing things at times, headaches, decreased appetite, stomach upset, all AT TIMES, not all the time so I never thought alot about side effects of Singulair. When the school started complaining I did look at side effects of Singulair and seen HYPERACTIVITY and mentioned it to his pediatrician and she shrugged it off saying she never heard of it being a problem. She's a great MD so I listened to her because his asthma was bad when he was younger and it is now under control. But then I think maybe he is outgrowing the asthma. I am afraid to stop Singulair and him have breathing problems again but then I can't help this strong feeling in my heart that says this may have been his problem with everything else all along. We are going to stop the Singulair tonight and see what happens. If anyone else has a child with asthma any suggestions for alternative treatment would be appreciated. I already know what's out there but sometimes it's nice to hear from another parent going through similar situs. Thanks for reading, Bobbie

I've never written on a blog in my life, and now that I've just read this, my stomach is doing flip flops and my blood is runnung cold. I have an 11 year old son and a 9 year old daughter. They have both been on singulair for quite a few years. My son has been on ADHD meds now since about a year and a half after starting Singulair because we tried to avoid them. Every few weeks he tells me he has this empty feeling inside him that makes him really sad and he doesn't know what it is. It just feels empty. I'll usually read with him or play a game or walk our dog with him to help him feel better.
As for my daughter, she exhibits all of the symptoms I have read about. She talks about life being terrible( trust me, she has it pretty good), she has been diagnosed with an anxiety disorder, OCD and Tourette Syndrome. Every psychiatric medication we have tried has made her worse. She was always a confident, outgoing little girl, and then she just changed. She's had stomach aches, which the docs always thought were in her head. She gets headaches. She is extremely sensitive, won't let me even brush her hair or touch her. She has extreme mood swings and gets upset over the most miniscule things, then writes about them, even saying she realizes her anger was too much for what the situation was! I will stop Singulair immediately and see what happens. What a miracle it would be if all of their symptoms disappeared.

My daughter, a happy, stable 13 year old had been taking Singulair for many years for her allergies. Last summer she suffered deep depression with symptoms including self-mutilation ans suicidal ideation. She had to be hospitalized and is now on anti-depressants and in outpatient treatment. I stopped her Singulair as soon as I read the stories at the end of March.

My 9 year old son was on Singulair for about 4 weeks. His whole personality changed. He cried all the time, he would not sleep alone, he had headaches, dizziness, tummy aches and horrible nightmares. His whole bodyy broke out in a rash and even now after 2 months of taking him off he is still covered in a rash. He was so sad all the time and so irritated. He would yell at us and was so angry all the time. He still is not back to himself. I see where people say their kids are back to their old selfs. I know my son is better but he still is having a hard time focusing in school and crys easily. He seems as though he is not the same child. I wonder if these side effects can cause permanent damage in some way. This is all so scarey. Drs. need to talk and help these children, NOW

My 9 year old daughter has been on singulair for about 5 months now and she is moody and not a very nice person sometimes. Now she in complaining of headaches and even cry's with the pain I want to take her off but I am a bit scared that if I take her off to quick this might be harmful can anyone let me know if they had any problems when they stopped their childs singulair.
Worried Mum
Australia

Hi guys,
I came to this forum after a client at our firm told me to check out whats happening with singular. I am not a lawyer, but I am a secretary for a med mal firm and I can tell you that we have already started taking these cases. I saw a few questions posted about whether you had to wait 9 months for the investigation to finish, but that doesn't stop you from filing suit. If it were my baby boy, I would switch meds, but if you can't--make sure you journal EVERYTHING. Take videos of outbursts, etc. We have one client who's son is self mutilating after using singular. If thats happening to you, try to document the episodes. Like I said, im not a lawyer, but I work for some so I can answer a lot of questions and I would be more than willing to help. I am so disgusted by what I have read. Please email me if you have any legal questions, etc. If i can't answer them, my boss will and if its a medical question, we have a staff nurse so I will give her a call. Again, I am so sorry for what everyone is going through. I pray to god I can help in some way.

Oh my gosh, I am just shocked after reading these posts. I am taking my son off of Singulair immediatedly!!!! I knew I wasn't crazy!! My son was on Singulair for over 2 years and it was awful. He was so hyper and uncontrollable. He couldn't control his temper. He had headaches everyday. He was put on it due to severe allergies and asthma. He is on other medications as well as allergy shots. I kept telling the doctor that I think the singulair was causing his bad behavior problems. He was just so hard to handle. He couldn't sit still for anything. The teacher couldn't get him to sit still in his chair. It just wasn't normal behavior for him. The teacher even thought he had ADD!! I didn't accept that however. The doctor just thought I was crazy and told me that Singulair wouldn't cause those symptoms. She said it actually would work opposit that and cause him to be sleepy. Well I took him off of it anyways and he did get pretty sick. His asthma acted up ect. But he eventually felt better and his behavior improved drastically. He wasn't so hyper and he could actually sleep at night and wasn't so scared at night. Just within the last week he has been pretty sick due to allergy season, his asthma has been bad and the doctor told me to put him back on the Singulair. So I did he has been on it for four days now and he is HORRIBLE.. It was an instant change. My husband and I can't control him and he can't sleep at night and has headaches every day. I am so glad I found this sight. I am taking him off immediately.
Thank you all so much for your comments. This medicine should be outlawed. I don't care what the doctors say. By the way my son is 9 years old. I certainly had no idea that it has caused suicide. I am so sorry to you all that have experienced such horrible things. Come to think of it my son used to say he hated himself all of the time when he was on this medicine.
God Bless You All

My son is three and a half and has been taking singulair for a little over two years. But only when his seasonal asthma flares up or when I know it is that time of year that he has problems. While taking singulair he has always complained of headaches, stomach and leg pains, and of course it never occured to me that it could be a perscribed medication. However after hearing the affect it had on another little girl and that leading me to research it to find all of these postings from other parents. What really brought on the investigation is the last week. My sweet little boy turned into a monster. He kicked, hit, screamed, pinched, bit, scratched or anything he could do to physically hurt you. We were all freaked out by this because he is such a sweet, gentle little boy, one of his teachers made every excuse she could think of. Because this was not in his character at all, then of he did it to her. She described it as a switch going off inside him. I believe he was also hallucinating, he told me someone told him to do it. This is by far the most scary thing I have ever been through and will never give my son singulair again. Further more I am going to pass this information along to all my friends and family and hope and pray that it makes is to everyone so this madness this perscription medication causes.

My 13 year old son has been on Singulair for about 4 years. I considered it a wonder drug because he would always get sick from his asthma. For the past couple of years my son has been very inattentive. I blew it off as the preteen hormones. It wasn't until recently his dad made a comment about him never smiling or enjoying things they use to do together. If you saw any of his recent photos compared to his past pics, he appear dazed and depressed. I would always ask he's okay, any new changes in school. OMG! I can't believe they are marketing this medicine to our children.

He always complained of stomach upsets, really bad headaches every week, pain in his legs and hallucinations. I know this sounds crazy, but I would have never considered it may be the medicine, but after reading the blogs, I'm starting to realize it could be contributed to Singulair. It's been two days since I've taken him off Singulair and I can only hope and pray his asthma does not flair up like it has in the past. I also pray that Merck is reading these blogs and will take Singulair off the market until a more detailed research is conducted. I at one time looked at Singulair as being the greater good for my son's asthma, but it's not worth risking my son's mental health. I wonder if Merck would give this medicine to there children?

My son is off singulair for two weeks now and is showing improvements. He was on it for 7 years and at the beginning we blamed it on steriods, even though his dose was low. When he went off the steroids, the behavior didn't stop. I questioned the allerist if the singulair could be doing it, but was told no, it doesn't have those side effects. I don't blame the doctors because they weren't given the info. He was extremely emotional, cried for no reason, had no confidence, didn't like himself. We on more than one occasion have told his older sister that when he hits his teenage years we would have to watch him for suicide, as his reaction to problems was sooo out of whack! He was on motrin for headaches 4-5 days a week(blamed it on sinusses). Unexplained stomachaches. These symptoms came on over years, not right away. I have always thought that the steroids had done damage because he took them when he was so young. Until the news reports hit, and I started reading other people's stories and doing the "OMG, that's my kid!", I never put the problems on singulair. I was still skeptical, but took him off. His symptoms immediately got 100x's worse for a week. But funny thing is, his headaches are gone, his stomachaches are gone and he seems much less emotional. The strangest thing is, EVERY night, he comes in to kiss us good night 7 or 8 times, and sometimes by the 7th time he is crying and can't explain why. This has been going on for YEARS, EVERYNIGHT, never a break. It stopped! Just stopped cold 7 days ago. Comes in once, says goodnight, leaves and falls asleep. I know this isn't a coincidence. After years of wondering what's wrong with my kid, now I feel like I've been poisoning my him for 7 years. I'm not skeptical anymore.

My 6 year old son has been on Singulair for 2 years and I have noticed a big change in his behavior but it all started with leg cramps and falling down alot..I told my dr about what was going on but she told me that it was nothing to worry about that it is growing pains..Before he started the on the singulair he was always a happy go lucky kid never had problems with him back talking or ever really getting angry. Now that I read all these reports these are the problems I have with him now:
My child has never offered to hit, kick or slap me but in the past year he has gotten more aggressive not only toward me but others as well..
He is fearful of people now thinking that they are being mean to him or picking him out to pick on or make fun of.
He has problems of headaches on a regular basis but just thought it was due to his sinus infections...
I have also noticed that my child has started hurting himself like punching even slapping himself in the face when he gets really angery or fustrated about things..
Sometimes he has problems with nightmares but not that much..
He also has problems with stomach pain as well...
My concern is taking my son off Singulair with his asthma being under control right now and he just recently had sinus surgery but I think it will be the best thing for him just because I want my sweet child back not the aggressive and abusive child he is now.... That is why first thing in the morning he will be taking him to his dr to find another medication to put him on and take him off the Singulair....

Both my children, ages 4 and 7, are currently taking Singulair chewable tablets for their seasonal allergies. They have been doing so for about three months. At first, I was not consistent in giving them the medicine. It wasn't until recently that I decided I should give it to them as prescribed, once daily before bedtime. During this time I heard about an incident linking this medication to a suicide. I shrugged it off thinking this could not happen to my children. Little did I know that this medication has other serious side effects linked to it. For the past few weeks, my own 7 year old daughter has experienced many of those side effects including stomache aches, headaches, trouble falling asleep, irritability, mood swings, crying spells, and traumatic nightmares. She used to be a fun loving child who loved waking up to go to school. Now she does not want to get up in the morning and hates going to school. She cries easily over the smallest thing and complains frequently of headaches and stomach aches. My son on the other hand has become overly aggressive and I had concluded that maybe his video games or cartoons were to blame. Well, today I found your website and I will take them both off the medication indefinitely! Their allergies were not as severe to begin with so I figure that they should do okay without it. I will probably look into more natural/ herbal remedies to soothe them when they do get their allergies. I will definitley be reporting back as to their results.

I am updating as my almost 7 year old son has been off Singulair for a little over a week now. He seemed to actually go through a "withdrawal" period for about 2-3 days. He was very emotional with his moods swinging wildly, giggling uncontrollably one minute, and then crying at the drop of a hat. Thank goodness we did this over a weekend so his teachers didn't have to deal with this! His stomach aches continue, but they don't seem to have the intensity they did before and this morning he even said to me that his stomach hurt and he was trying to figure out if he was just hungry or had an actual tummy ache. I gave him a small breakfast and he said, "Yup, I was just hungry, it's gone now." Before, he couldn't ever tell if it was a real stomach ache or if he was hungry. His stomach just always hurt. He did have two nights in a row (the first two nights w/o Singulair) with really BAD nightmares--even came into our room crying both nights. Since then, he hasn't woken once during the night. My husband and I can't remember the last time we went a whole week without our son ending up in our bed!! No complaints of headaches, leg pains, no sinus infections, etc. So far, I would say that he is getting better--the side effects, at least. Because our son is severely asthmatic however, we do take peak flow measurements 3x every day. Since going off Singulair, his peak flow hasn't been as good. Not terrible, but not as good.

Interestingly, I spoke with both our pediatric pulmonologist and our pediatrician's office. Our pulmonologist was very supportive in going off the medication as long as he had other controller meds (which he does). Our regular doctor's office has two pediatricians, one was very interested in what our pulmonologist had to say, what our son's side effects were, and was supportive of our pulmonologist's decision, etc. (She's the one we always see.) The nurse told me that the other ped. was not recommending that ANY of her patients stop taking Singulair. The ignorance of some doctors--lesson learned for me. Never see that pediatrician!!

The tough decision for us will be what to do if our son's asthma gets worse with recurrent pneumonia and hospitalizations for URI's returning. We are hoping that doesn't happen and that we can find other ways to help control his asthma! I still feel that Singulair was the most effective in controlling his asthma--just don't think we can put him through all the stuff that seems to come with the Singulair!

chris555 should be listed as a side effect. I'm one of the ones whose son committed suicide while on singulair and had the mood swings and such before hand. chris555is causing headaches and making people sick because chris555 is an ass!

Wow. I can't even express how blown away I am by all of this.My son is 7 and has been on singulair since he was 2. He was moved to the 5 mg last year in March. The only difference between my son and all of your stories is that when he was in kindergarten we discovered a rather large arachnoid cyst in his brain that had to be drained. It was easy to blame some if not all of his behavioral problems on the location of the cyst. It is in the left temperol lobe. Having something in that region of the brain can cause behavior problems. His cyst was also big enough to push on his pituitary gland making him think he needed to use the bathroom all the time. He had a slight case of diabetes insipidus. During all of this he was complaining of headaches, fatigue, leg pain, the boy could not walk from one end of the mall to the other, he would melt down at the slightest provocation and turn into an angry little monster at around diner time. We attributed it to low sodium levels messing with his head, but his blood work never reflected someone who was THAT bad. After his surgery he had some normal depression, but in March, four months after, he became a different person. He was full of rage and anger and almost got kicked out of school. He broke things at home and lashed out at people, he said awful things. He was put on Tegretol, (that made him very sick) and Wellbutrin. Since he couldn't tolerate the tegretol they switched him to abilify. He still takes this. The one time we tried to take him off he went completely nuts again. Same kind of aggressive behavior, lashing out, no self control, crying all the time, very moody, saying things like "nobody loves me." My son is the sweetest person you will ever know. Before all of this, he would melt your heart with his kind words. Now he has been diagnosed with ADD, Aspergers, and has all of one friend at school. I go every day to eat lunch with him so he doesn't have to sit alone. I completely understand that my son will continue to have problems once this medicine is out of his system, because he does have other issues, but this morning the first thing he said to me was, "Mom it's weird, I don't know why but I feel so happy."
He has been off the Singulair for 6 days now. I called his allergist and he was VERY interested in all of this and wants to meet with me. He has always been so heartbroken by how my son has struggled. Don't think all doctors are bad. This one isn't. He is going to help me report all of this. He is really upset too. Of course he is older, been around for ever. I don't know. He cares about his patients. His receptionist said she thought they would be getting a ton of calls about this and I was the only one. Hang in there everyone. Alone we are quite together we are LOUD.

Both my son and I were on Singulair. As of Sat March 31st we both stopped taking it. My 6 yr boy has been on it for apprx 3 1/2 years for allergies along with nasonex and claritin when needed. He started pre k after being off the singulair for the summer. His first 3 weeks of school had no complaints. 3 weeks into school he started singulair and teacher immediately noticed the difference and brought it up to dr's who said it had nothing to do with his behavior. Over the years he has experienced, problems with excess urination after taking dose at night causing exploding pullups.. changed to day time and that helped somewhat. nightmares/ hyper /moody, irritable, leg pain, stomach pain,angry outburst (he says his brain made him do it), headaches, stuttering,sinus infections that he finally had his adnenoids removed in Feb.. He started kindergarten last Sept and it has been a nightmare..I tried to take him off Singulair in Oct but due to his enlarged adenoids his allergy symptons became so much worse I put him back on. The last few days where up and down as the Singulair was coming out of his system but I was seeing improvements.. Well I decided today to remove him also off the nasonex as I have read similar side effects about the nasonex. He had a pretty good morning today and went to school and came home for the FIRST time all year with smileys for the entire day!! I am overwhelmed with emotion! So happy that he is coming out of the fog and guilt that I have been giving him this medication and didn't follow my Mommy instinct to stop it years ago! I had side effects as well to the point people were telling me my personality had changed. I was irritable, short of patience and having alot of headaches. The last few weeks I was having days of depression and crying over little things especially with the stress of what my son was going through.... I am also coming out of the fog and happy to be back!

My six year old daughter has been on Singulair since she was one. She has bad stomach pains, headaches, mood swings, not being able to do school work and anger. I had thought about taking her to see a therapist. I didn't know what to do about her anger and mood swings. After reading everyone else's post, I feel like that it really could be the Singulair. I have taken her off of Singulair. I will not put her back on it. I pray that she will feel better soon.

Update: My daughter has been off Singulair for 3 months and is doing so much better. She is not having anymore nightmares, heart racing, anxiety attacks. No more itching, headaches, stomach pains, depression. She is so much happier now. She is 7 years old and acting like a happy child now. I am so glad that I took her off it in December. She is not crying and upset like she used to be. We could tell that she improved within one week and is still improving. Hope everyone else improves like my daughter has.

My daughter, who is 9.5 has been on Singulair for the last 6 years. I am saddened that I was so frustrated with her for all of these bizarre behaviors that I never even thought to link to this medication. My daughter has severe allergies, and her asthma is triggered by her allergies, so to that end the medication worked beautifully in controlling the asthma. But, it is not worth the aggressivenesses, horrible mood swings, suicidal thoughts, depressiveness. She has frequent temper tantrums that mirror those of a two year old. I frequently have asked her when she will outgrow this phase, it seems she never moved passed it. Then a moment later, it seems as though she has the drama of an adolescent girl, including the depression and even the extremes of threatening to run away from home and that she would be better off dead. This has been going on for years, and I never connected it to the Singulair. I just thought there was emotional problems, and that I was a bad mom, and that I just needed to keep being consistent and reassure her that she was loved, but that her behavior was not acceptable. She has very low self esteem one minute, and incredible confidence the next. She is very argumentative all the time, about everything. She also talks and sometimes walks in her sleep. She tends to get up 1-3 times per night, and has no recollection of it ever. She has begun to develop stomachaches, headaches, and leg cramps recently.

My son, who is 6.5, and has ADHD, now is starting to mimic some of the things he has heard her say, and it is difficult to undo this damage.

Again, I never connected any of this to Singulair, I just thought I had a challenging child. I pray for all of our children that the damage is not permanent, and that there is a safe alternative that we can have faith in. I know it will be difficult for me to trust another medication.

My deepest sympathies to those families who have lost a child to the perils of the side effects of this medication that were not disclosed to us.

First, I would like to tell you what my daughter used to be like. My daughter used to laugh, smile, sparkle and she loved life! My daughter was smart, as her pediatrician had been telling us since she was one. She sailed through life! Then we had hurricane Isabell come through, and she was rushed to the hospital in the middle of that storm for our first asthma attack. She was three at the time. We took her to a Pulmonologist, which she has seen since. She is now 7 going on 8. She was put on Singulair about 4 years ago. Starting kindergarten was pretty much a breeze. First grade came and she complained of headaches, stomach problems, trouble concentrating. Telling me "mommy I can't think". I asked her Pulmonologist, 5 times that year if it were any of the asthma medications. I was assured it was not. now we are in second grade, and she has steadly declined in every aspect of her life. She started having "eye darting" and head movements, which she was unaware of over Christmas. Her teacher kept saying there is something wrong, "but I can't put my finger on it". She retreated from family and friends. Since December we have been through a slew of testing. The first was an EEG, next came an MRI and lastly an 24 hour EEG. All looking for seizure activity. She has seen a pediatric Opthamologist. She has been through testing for ADD....this being the last. She had a serious reaction to an ADD medication last week. When my daughter asked me "mommy, why did God make me this way", the tears just wanted to run. I had no answer. My husband and I both feel that it is NOT ADD! Let me add some facts here...she can not concentrate, she can not focus, she has withdrawn, she has started to have anxiety, she is weepy one minute, and agitated the next, she can not stay on task and finally her grades are dropping to the point of retention. My heart aches for her, I feel helpless. I want to see my girl back, I want her happy smiling face back, I want her to be confident again. I just pulled her off the Singulair last night, after my sister left many phone messages concerning this blog. I have read them with the love only a mother knows, and the pain for each and everyone of you going through this. As I sit here and type this, I can only have hope. This is very difficult to write, and I am not even sure if I have written it all down. What I do know, is that at 2:00 AM last night I took the time to report her side effects to the FDA. Today is a new day, and I hope and pray for my daughter and everyone of you out there dealing with this.

Terry A