Singulair and depression

My son is 12 and has been taking Singulair for the last ten months...he has been getting moody and upset for no good reason over the last 3 months and I put it down to "hormones" starting to kick in. He has now gone to feeling very sad and has even told me last night that he has thought about killing himself several times and feels he can't go on, or cope and feels lost and lonely or unwanted and in the way. He is confused and does not understand what is happening to him. I have just realized it may be the Singulair and will be taking him off it immediately. I'm hoping it is this as if it isn't I feel totally helpless as to how to help my child. Please say a prayer for him. He used to be happy go lucky.

I would like to know who is NOT experiencing side effects from Singulair.
We are not.
My 7 years old started Singulair three months ago because of allergy issues. She had asthma attack every other week, running nose all the time, she was so miserable, she missed many days of school and she couldn't exercise .Since she started to take SIngulair her allergy improved, no more asthma, no more running nose. SIngulair did not change her way to be. She is doing very good in school (she is above the average..) she does piano, ice skating, she is purple belt Tae Know Doe, speak two languages, she is doing great in everything. Of course she has her "bad moments" but which child does not?
I tried homeopathy, but it did not work, she got worst and worst. I was supposed to give SIngulair to my daughter a year ago, I did not because I was afraid of the side effects. But I wished I had started before because I could have avoid so much steroids since she had asthma most of the time. The doctor convinced me to use this medicine when she said " You think SIngulair has side effects, yes sometime it does, but do you know the danger of using steroids so frequently in a little body?" Then I thought I had to give a try. I am glad I did. Of course I keep watching my daughter behavior closely and reading all the possible side effects of this medication. I forgot to say that beside singulair my daughter is also taking Pulmicort, two puffs once a day.

My husband has been taking Singulair for the last two years. It has made a tremendous difference in his frequency of sinusitis in the winter and allergy symptoms during the summer and fall seasons. For at least the last year, he's been having trouble with insomnia, so he is taking Melatonin. This helps but last night something very new happened. We went to bed around 11:15 p.m., then at 12:45 he woke me up and said he was having trouble breathing. He was very agitated and paced around the room, would sit for a few minutes, then get up again, pace and act very agitated. We've been married for 26 years and this is not normal. We almost went to the emergency room but decided to wait. This morning he's tired and very quiet. From reading the other postings, I think that Singulair could be causing the insomnia and now the agitation and depression.

My 7-1/2-year-old son was on Singulair for 5 months for asthma and possible allergies. He had been on medication for ADHD for almost a year at that point and had been doing well with it. Singulair made him into a monster. He could not be reasoned with and was constantly overreacting to everything. Just asking him to put on his shoes caused explosive reactions, even to the point of threatening us (his parents) with bodily harm if he did not get his way. We unexpectedly stayed the night out of town and did not give him his Singulair for a few days and started noticing that he was much more rational, calm, and more like his old self. I had heard of the depression risk with Singulair and googled about it this morning and was floored by the amount of children with these type reactions. It is now listed as an allergy for my son and I will never give it to him again.

It seems that this subject has been extensively documented, but just wanted to confirm that I believe this drug is very dangerous. We JUST put our 5-1/2 year old daughter on it one week ago. She has NEVER had any issues sleeping, is most often in a great mood, and has been protected beyond belief by my wife from negative imagery, TV, etc. The last week was unbelievable. Night terrors every night, with the most vivid and negative imagery when asked to describe the content of her dreams. Things that I would have thought she must have gotten from watching a Stephen King movie. Given the lack of fitful sleep could have been a contribute, but her mood all week was very downtrodden. Hard to say a 5 year old can be depressed, but I would have to say she was, very sullen, moody, despondent to affection.

I can positively say this was a blind test. We didn't really read the label on the medicine until yesterday, so we were not looking into things that weren't there, nor were we focusing in on the sleep issues. We took her off yesterday, and hopefully I will be able to report that the night terrors that I am 95% positive must have come from this drug will abate.

I hear because the chewable format is new, this drug is really being pushed. I hope this drug is pulled instead of being promoted. Buyer beware, especially administering to kids. I can't imagine if our daughter had been a little younger and not able to express herself to the level she can at 5.

Im 15 and I never knew that singulair had the side effects that included mental/mood change or worsening depression, etc. Although I did find it strange that I always seemed moody or bi-polar, it never occurred to me that it would be caused by singulair. I've been taking it for about 3 years and before I went from 5mg to 10mg i use to have difficulty sleeping, but just last October when I started taking the 10mg i noticed an even greater change in my moods and mental thoughts, i was always sad, doubtful, mad, and was always thinking of all the negative things in life, in fact I even went through a really deep anxiety stage around the end of October, it was a mixture of the medication and stress i'm guessing, but I couldn't stop crying, I'd cry then forget the reason, start crying again, and wonder what i was crying about or why i was crying for such a thing that lasted for about an hour... Then when I ran out, i sort of just put the thought aside to refill them for the whole month of November and noticed i began to feel more... up-beat, very happy, I cant remember the last time I felt so great for such a long period of time, at least not during my pre-teen through teen years so far. All my friends noticed too, normally i would be complaining about how the day is going so bad, but i can't compare November to any other month during the past almost 3 years, although my asthma symptoms came back. So I started taking them again this Monday, and right away that night when I was doing homework, i was studying about tabacco all these thoughts rushed through my head, I felt bad for the people i loved that smoke, and I started crying, almost blaming myself for their smoking, when i stopped crying i started wondering why i cried... it made no sense, normally i'd just be like, "oh man... why do they waste their time doing that.." and forget about it, but the tired, sad, doubtful feelings came back right away. these past few days I've felt like that, and today before i was about to take my pill i looked at some new information that was never included before about the mental/mood changes, worsening feelings of sadness etc... and it all just hit me like a ball going 90mph.

I was surprised to hear that Merc, the maker of singulair update their side effects 4 times in one year to include depression, anxiety, suicide, and suicidal thoughts. It was prescribed to me cos of my allergies and asthma. I never really took singulair on a daily basis because it made me feel so tired and out of it. So i would only take it when my allergies were very very bad, like having a bad sneezing fit or nose would be runny non stop which would be at least 1 to 2 times a month. My asthma wasn't really that bad, i would get it when my allergies would act up like i mentioned before. When the fires in California were going on my asthma started acting up because of all the ash in the air. I was having asthma attacks every day. Since singulair works great for asthma i started to take it everyday and noticed my asthma went away. The first couple days were fine..and after two weeks i started noticing i was becoming anxious and irritable. Also depression sunk in...So i wondered what was causing it. I wasn't going trhough any major life changes. So i looked up singuliar side effects and noticed the four new side effects that i mentioned above...I stopped taking the pills to see what would happen and i felt emotionally better but the asthma came back..id rather suck on my inhaler then be anxious and depressed.

Oh my gosh. I am on this website because I googled "behavior issues with Singulair" Both of my children are on Singulair. One from as young as 5 months old. Both Pulmonologist, allergist and Internal med Ped. insisted that it was a safe drug. They aren't living with it. My 7 year old has taken it consistently for 5 years and recently upped is having behavior, aggression, insomnia and constant reports back from the teacher on his behavior. We had him psychologically evaluated and they found nothing uncommon to his age. All his issues are described in almost everyone of these side effect threads. I am just afraid to take him off and feel the blame if something serious happens. I am calling tomorrow for possible alternatives.

I was put on Singulair about three weeks ago, and noticed immediately that my mood had changed. I am an adult ,and felt this sense of sadness, anxiety, solitude, not wanting to be around anyone. I took myself off the drug and have tics all over my body and eyelids ,which is driving me crazy! I even had heart palpitations ,which are very distressing. Today it seems to be better, and this is day three off the med. The only way I can explain how I felt on this drug is doom and gloom.

I was first given Singulair at the age of 21. At which time, I quit a job in which I have yet (at 28) to match its income. My doctor continued to give me samples as I could not afford the medication. During this time, I was very depressed, contemplated suicide often and was given a serious of antidepressants-non of which helped. For one reason or another, I stopped taking everything. At which time, it seemed I had a new lease on life. I went back to college, finished my degree, and got a job in decorating. My asthma began acting up again, and again I took singulair and again had to be given antidepressants. I wound up quiting that job too and worked a serious of low paying jobs. Again, I quit, and again found the urge to "live" again. I never connected the two, until this past week. I was given singulair again by another doctor on Wednesday. Thursday I had nightmares, Friday I spent the day crying, Saturday night I began to think of leaving my husband (I also did that ALL the other times I took the drug and we've been together 14 years-I love him). Today is Sunday, I normally go to bed around 12 or 1 a.m., but I am making myself stay awake and have all day. This drug has ruined a large part of my life, please, if anyone notices even a little depression with this drug, Stop!!!! It is not in your head, it is this drug!!!!

My son is almost 4 but has been on Singulair since he turned 3. We saw an immediate improvement in his allergies and asthma and thought it was a miracle drug. That is until we started to see our sweet, outgoing little boy change into something we barely recognized. We thought maybe it was just a stage he was going through or something and didn't connect it to the Singulair until his doctor accidentally wrote his refill prescription for 5 mg. instead of 4 mg. After about 2 weeks on the 5 mg. his mood swings increased substantially. He cried for hours everyday at school. He had previous trouble with his emotions at school on the 4 mg. as well. He continued to cry and throw fits at his preschool so often that he was ending up in the principals office. At home, he became clingy and so emotional that he would cry about everything. After doing some research on Singulair, I immediately took him off the drug. Within 1 1/2 weeks off of the drug, my little boy was a different child. I thought maybe I was the only one who had noticed until his teacher came to the car and ask what happened. She said that he didn't even resemble the same child that started school. He is sweet, and calm. He can take discipline without crying and gets praise every day instead of going to the principals office. His trouble sitting still and listening to the teacher are gone and her push for us to have him tested for ADHD has ended. He is now a star student. The only difference is the removal of Singulair from his little body.

I notice vivid dreams/night mares the first night. The second day I notice thoughts of running of to very far places. The third night severe chest pains, extreme anxiety, irritability, and thoughts of suicide. Now I have been treated for depression in the past but never attempted suicide. After the third day of singulair i wanted to take a gun to my jugular vain in my neck and pull the trigger. Oh the joy of a panic attack.

I am re-posting this from June. I believe that we have many reasons to suspect that Singulair does indeed penetrate the blood brain barrier. I personally believe that under certain unusual conditions that Singulair can cause neurological damage. I tried before to put together a scenario of brain biochemistry that could explain how this can happen. Of course, I am just hypothesizing and all of my ideas will not prove to be totally correct. From the number of postings here regarding neurological symptoms, I believe that there is an answer out there somewhere. Why the FDA is not searching for this answer is a complete mystery to me.

I believe that it is possible that Singulair causes the same biochemical response in the brain that is cited in this study -- thus causing neurological damage.

"Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicity may contribute to neuronal death in neurological diseases."

IS SINGULAIR CAUSING THE DEATH OF NERVE CELLS IN SOME PATIENTS? DOES THIS HAPPEN - ALTHOUGH INFREQUENTLY- BECAUSE OF GENETIC OR BIOCHEMICAL FACTORS OR BOTH?

June 12th
2008
2:56 AM
I have stated many times that I am not an expert. I just post what I find. This has been a mind boggling journey for me. This is way over my head but I struggle to read and understand. Finding answers to why children are suffering from neuro-psychiatric side effects is worth the effort.

I have made the following observations.

1. Some quinolines are known to be able to cross the blood brain barrier.
2. Molecules that ionize are known to be more likely to be able to cross cell membranes. So if montelukast ionizes as a result of change in blood pH to sufficient acid conditions, then it could be possible that it does in fact cross the blood brain barrier.
3. We know that there are cysLT1 receptors in the brain.
4. We know that researchers believe that montelukast may bind at the arginine of the cysLT1 receptor.
5. We know that arginine contains four nitrogens. And montelukast contains one.
6. We don't know what happens to those nitrogens. Are those nitrogens converted to nitric oxide?
7. We do know what macrophages create nitric oxide as I posted.
8. We do know that if something cause excessive nitric oxide to build in the brain that there would be damage to the neurons.

Some people may remember when I got stuck at the astrocytes, the cysLT1 receptors and glutamate. I keep looking for research reports that may shed more light on this.

Titre du document / Document title
Nitric oxide causes glutamate release from brain synaptosomes
Auteur(s) / Author(s)
MCNAUGHT K. S. P. (1) ; BROWN G. C. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Biochemistry, University of Cambridge, Cambridge, ROYAUME-UNI
Résumé / Abstract
We determined the ability of pathological levels of nitric oxide (NO) to cause glutamate release from isolated rat brain nerve terminals using a fluorometric assay. It was found that NO (0.7 and 2 μM) produced (4 and 10 nmol/mg of synaptosomal protein) Ca2+-independent glutamate release from synaptosomes (after 1 min of exposure). Spermine/NO complex (spermine NONOate; a slow NO donor) and potassium cyanide (an inhibitor of cytochrome oxidase) also caused Ca2+-independent glutamate release. Preincubation of synaptosomes with 5 μM 1H- oxadiazole quinoxalin-1-one (an inhibitor of soluble guanylyl cyclase) had no effect on NO-induced Ca2+-independent glutamate release. Ca2+-independent glutamate release produced by NO was greater in a low-oxygen medium. NO, spermine NONOate, and potassium cyanide inhibited synaptosomal respiration with a similar order of potency with respect to their ability to cause glutamate release. Because NO has been shown previously to inhibit reversibly cytochrome oxidase in competition with oxygen, our findings in this study suggest that NO (and cyanide) causes glutamate release following inhibition of mitochondrial respiration at the level of cytochrome oxidase. Thus, elevated NO production leading to mitochondrial dysfunction, glutamate release, and excitotoxicty may contribute to neuronal death in neurological diseases.
Revue / Journal Title
Journal of neurochemistry ISSN 0022-3042 CODEN JONRA9
Source / Source
1998, vol. 70, no4, pp. 1541-1546 (29 ref.)

INIST-CNRS, Cote INIST : 4037, 35400007527188.0230

I also have a child who has been on this drug for about a month and as I sit here and read these blogs the more I am remembering complaints made by my son. He has been getting into trouble at school lately, irritable, angry, sad, leg pains, stomach aches and also having trouble getting to sleep at night. I am an RN and it took me to glance at the pill bottle today to realize that I needed to do a little more research about this drug when I saw that it said "mood changes and depression". I feel horrible because after a great 2nd grade year I was disappointed that he was not behaving as well this year. I know know that the $60.00 wasted and tiring reprimanding was all a waste of my time! I owe my poor son an apology as I will be taking him off of this drug today! More information and advocacy needs to be available especially when core users are children who have little to no voice!!!

d27gayle POSTED INCORRECT INFORMATION ABOUT THE SIDE EFFECTS OF SINGULAIR. I JUST COPIED THIS FROM MERCK'S SINGULAIR WEBSITE. THIS IS THE CORRECT AND UPDATED INFORMATION. THIS INFORMATION DOES LIST DEPRESSION AND SUICIDAL BEHAVIOR AS SIDE EFFECTS.

IF PEOPLE ARE GOING TO SHARE INFORMATION ON THIS SITE, PLEASE MAKE SURE IT IS CORRECT BEFORE POSTING!!!!!!!!!

What are the possible side effects of SINGULAIR?
The side effects of SINGULAIR are usually mild, and generally did not cause patients to stop taking their medicine. The side effects in patients treated with SINGULAIR were similar in type and frequency to side effects in patients who were given a placebo (a pill containing no medicine).
The most common side effects with SINGULAIR include:
• stomach pain
• stomach or intestinal upset
• heartburn
• tiredness
• fever
• stuffy nose
• cough
• flu
• upper respiratory infection
dizziness
• headache
• rash

Less common side effects that have happened with SINGULAIR include:
• increased bleeding tendency
• allergic reactions
• behavior and mood related changes
• drowsiness, pins and needles/numbness, seizures (convulsions or fits)
• palpitations
• nose bleed
• diarrhea, indigestion, inflammation of the pancreas, nausea, vomiting
• hepatitis
• bruising
• joint pain, muscle aches and muscle cramps
• swelling

Rarely, asthmatic patients taking SINGULAIR have experienced a condition that includes certain
symptoms that do not go away or that get worse. These occur usually, but not always, in patients who
were taking steroid pills by mouth for asthma and those steroids were being slowly lowered or stopped.
Although SINGULAIR has not been shown to cause this condition, you must tell your doctor right
away if you get one or more of these symptoms:
• a feeling of pins and needles or numbness of arms or legs
• a flu-like illness
• rash
• severe inflammation (pain and swelling) of the sinuses (sinusitis)

These are not all the possible side effects of SINGULAIR. For more information ask your doctor or pharmacist. Talk to your doctor if you think you have side effects from taking SINGULAIR.

My daughter was prescribed Singulair in the spring and it worked wonders.Since her allergies and asthma don't bother her in the summer I took her off for those few months.Since she has been back on the last few months I notice once and awhile an aggression/depression behavior.I thought immediately that it was Singulair causing this but it wasn't everyday it happened.I believe that activity,schedule,and even food in combination with this medicine that was cause this rare effect.It's no news to parents that all of these things can change a persons attitude and behavior.I also believe that Singulair may just make people more sensitive to their true self as my daughter has always been paranoid and has lacked self esteem.I think that it is trial and error as with any medicine.Try it and it may or may not work for you.Taking it off the market would be a disgrace as it has saved many lives.

Last Sunday I attended the American Foundation for Suicide Prevention (AFSP) walkathon in St. Paul, Mn. I was able to hand out hundreds of flyers to survivors of suicide and people in the mental health community. Of the hundreds of flyers that I handed out only two people had ever heard of the link between Singulair and these various side effects that we have all noticed. I received some wonderful responses and many people offered to make copies of the flyers and hand them out to everyone that they know. Several people worked in the mental health community and in pediatric offices and they were going to tell all of their coworkers about Singulair.
I also had the opportunity to talk with Dr. Paula Clayton. She is the National Medical Director for AFSP. She said that they are aware of the concerns with Singulair and their organization is going to Washington this spring to express concerns about Singulair and several other medications that are linked to depression and suicide. She also stated that if everyone could write letters to their local representatives that it would really help to raise awareness.

headaches, dizziness, tic in an eyelid, depression, leg cramps

POLL: If you or your child have been adversely affected by Singulair could you please reply to this and let me know what ethnicity you are and skin tone. (fair, med., dark, etc.) I'm interested in the demographics of this drugs effects.
Thank you!

Along with uncharacteristic depression from using singulair for only a few months- I experienced ( and still now, after 1 week prior to ending my daily dosage) terrible lower calf cramps I have never experienced before. Not only do I get quick searing pains in my legs at night, but my calf muscles are very sore whenever participating in brisk physically activity. I hope these side effects will terminate shortly- because for an athletic thirteen year old high school freshman, depression, lack of energy and physical pains are not making the beginning of young adulthood a very enjoyable experience

My Daughter has been the same way .. she had the headaches, stomach pain, very depressed .. she has missed 6 months of school she was afraid to go to school, shopping, and being left alone.. I have put her on medication for her depression, and anxiety . i have her in therapy for this... she is not the same child i just want my beautiful daughter back..We are having a hard time with her from school to he social life.. and from her tring to kill herself.. My daughter is only 13 years old...I think someone needs to pay for this... please there must be help out there...How long must this go on before people (FDA, Merck, ALA, etc.) will take this seriously?!?!?!?!
I want my beautiful katelynn back........................
--

This past winter we found out that my son had developed asthma. His allergist /asthma doctor put him on Singulair as his preventative. Not two days later a report came across the news that Singulair has depression as a side effect. I immediately called my son's allergist / asthma doctors and was told that these symptoms have been found ONLY in children in their teens. That they are linking something in the med with hormones and it spawns depression.
Even though this is terrible for the parents of teenagers, my son is 6 years old... the chance of this happening to us was slim. Or so I thought.
One morning, to my horror, two weeks later my 6 year old son whom never really watched anything on television without his parents (with the exception of Noggin programs) is talking about how he wished he was never born. That no one would care if he was to die or disappear. That maybe he should just go to sleep one night an just die..... he was getting so angry for no apparent reason, throwing things and yelling all the time... telling me, his mother (we have always been so close) that he wished I were dead and that he hated me...
Needless to say I immediately called his doctors and they told me to stop the Singulair right away. The doctors were shocked that this has happened to a 6 year old and had filled out reports for the FDA that I had to give detailed descriptions of what happened to my son so they could start warning other parents.
Now, four months later and we have our happy go luck son back. No preventative, but the inhaler is doing the job.
Good luck out there if you agree to put your child on this medication. I understand it does not happen to everyone, I just cannot tell or describe to you how horrifying and traumatizing it was to go through seeing my happy go lucky son become this extremely depressed angry aggressive child within two weeks. We are still battling the aggressive behavior, but hey, he is 6 and that could be normal... right?

I also want to add that he has been having nightmares a lot as well. And exhibiting some behavioral issues on and off at school.

Again I can not tell you how scary this is. I have no clue where to start or what to tell my congressman. What do I say? Do I make specific reference to Singulair or do I just medicines in general? No offense, but right now my concerns are selfish, and I need to find another alternative to Singulair. I cant bear to have my son experience what I have to deal with everyday with my depression.

He says things like
"I hate myself" and
"This is the worst day of my life"

I am so scared I plan to call his Dr first in the morning.

I just came across an article on the online "Huffington Post" by Dr. Doug Bremner, who researched the connection between accutane and depression, called "If Prescription Meds Don't Kill You They Might Drive You Crazy" He explains the link between Singulair, Leukotrienes in the brain and depression. There are numerous articles by him as well that are definitely worth reading.

Jenna M.
Parents United for Pharmaceutical Safety and Accountability

I am 15 and have only been on Singulair for a week. But I have already had sever leg cramps and my foot locked into place for a few minutes with extreme pain. I had a nose bleed today too, which is not normal for me. I have also had really bad cramping which I didn't think anything of but now I don't know what to do because I have sever allergies to almost everything outside and this seems to be the only thing that helps. After reading all this I am freaked about everything. And I have been really moody this week, but I thought it was just because I am a teenager but now I don't know.

Well after reading these posts...I am very sad that I didn't read this before I allowed my 3 year old son to start Singulair! The last month he has been complaining of lower back pain. Just recently, stomach pain as well. Says his head hurts, and at times is not himself. I pick him up from preschool awaiting a very energized little boy to talk nonstop about what he did and he doesn't:( He was put on this med for allergies with Flonase and Zyrtec as needed. I took him to the doctors for this lower back pain and they said it possibly was from playing too hard or growing pains. Trusting our pediatrician I took it as that. My son continued to complain and continued to, at times, seem depressed. I took him to the ER because the last week and a half he has had fevers of 100-102. They said its all viral. I came home, looked Singulair up trying to figure out what was wrong and found all of this. I am so sad I never researched this before and continued to give this to my little boy trusting it to be good for him. Needless to say, I am making another appointment for him tomorrow to discuss other options. Thank you all for the information!

My wife and I recently took my daughter to an asthma specialist and she was prescribed Flovent and Singulair as everyday suppressive treatment. Our daughter is only 4 and the first evening of taking SIngulair she was exhibiting exaggerated emotional behaviors such as sadness and excessive crying (sad/moping). The following day the same emotional state was there without anger, but with abnormal crying (for my daughter). She went to preschool and her teacher said she was saying things such as, "I don't care", "I don't need anyone", "I hate this", etc. These are not normal behaviors for our typically happy child. Her doctor said suicidal thoughts and depression were possible side effects in adults, but I am beginning to think they apply to children as well. After only 4 days of Singulair we have decided to stop the treatment. I hope these comments help some of you other parents experiencing the same thing. -Rob

I am so glad I found this site. I went to an ENT this week for problems I have been having with my Eustachian tubes.She checked my ears and said they were fine (which they are not) told me I had allergies and prescribed Singulair. I picked up the Rx today but when I started reading the side effects I decided to do some additional research. If Singulair causes depression and suicidal thoughts then forget it! I already suffer with depression. Thanks but no thanks. I guess I just threw $25.00(co-pay) out the window but better that than deal with these nasty side effects.

I was searching for a site with the side effects of Singulair for my son who is 10 and has been taking Singulair since he was 2. It was a life-saving drug for him and his life has been wonderful since then (as far as asthma goes). He is a very athletic boy who plays every sport he can and he is still a little overweight with cellulite and love handles. I had heard that maybe it might be the Singulair so I decided to check it out. Little did I know about all of these other side effects. He's been taking it for so long that I assumed his depressed personality was just the way he was. He has also had such horrific nightmares and he's convinced he has a ghost in his room that shakes his bed that I was really starting to consider that maybe he might. His brother sleeps in the same room and does not have any of these experiences (also on Singulair). I am SHOCKED! I only read about 20 entries but I'm going to read more. Has anyone had the weight gain problem? Thank you for anything you can share.

Thank GOD for this web site.. I was just prescribed this medication today and I will throw them in the trash and not take one.. Thanks. I already suffer from depression.. THIS I didn't need.

My daughter began taking Singulair in 2003 for asthma and allergies. I slowly watched her deteriorate from a lively, intelligent, and outgoing young woman to a depressed, withdrawn and self-mutilating person who said that she hated herself and everybody else in the world. She was an athlete, a straight A student who had received an academic scholarship to college, she was fluent in German and had been teaching herself Japanese, and she was a staunch supporter for equal rights for children with disabilities and gay and Lesbian teens. On February 3rd, 2007 my daughter hung herself after working at the local community center. I no longer recognized who she had become. I have a degree in psychology, my father is a retired police officer, and my mother is a retired R.N. We were all trained to recognize the symptoms of depression and suicidal thinking, but we were never able to connect it to the medication that she was taking.We must all ban together to prevent other people from suffering the way that our loved ones have! Educate everyone that you know about what Singulair can do to you. They are still prescribing this drug to people without any notification of what the side effects are.

A few years ago Singulair was prescribed for me. I am 56 years old and generally healthy with asthma and allergies. Within only a few days I started to notice that I was very depressed. I was frightened at how hopeless I felt. After a couple of weeks I starting using a new drug. The terrible depression went away within a few days and I was my normal cheerful self. For some people, Singulair is a very dangerous drug. I will NEVER touch this drug again! I'd be especially hesitant to use it on children or teenagers that aren't as aware of changes in their moods.

Sept. 1 (Bloomberg) -- U.S. researchers found no evidence to support regulatory warnings that Merck & Co.'s Singulair asthma and allergy drug, taken by millions of Americans over the past decade, may be linked to depression or suicide.

The findings will be published in the Journal of Allergy and Clinical Immunology, the American Lung Association said in a statement on PRNewswire today. The study was sponsored by the association, which doesn't endorse products, it said.
HOLY COW

I just read an article dated 9/1/08 that stated that the American Lung Association just cleared Singulair as causing depression and suicide. They had researchers study the results from the original test trials because they are supposedly more accurate than after market reports. The article is at ******. I cried when I read this report. My now 8 year old daughter has been on this medication for mild asthma since she was 4. We have thought the stomach aches and tantrums were related to moving to a new town around the time she started taking singulair. But, 3 months ago, she all of a sudden started having depression, ocd about germs, afraid she might hurt herself and then depression and suicidal thoughts. She has been off meds for 8 weeks and still has some problems with thinking she wants to hurt herself and feeling down. She is normally very happy and our family is happy and normal, but dealing with this is difficult. How long does it take to get out of their system?

After taking a "leave of Absence" from this site, I see that Singulair is still up and thriving. I still see ads for it on TV, over and over again. They haven't been altered at all. Makes me sick. I wish there was away to get to other people whose children have died by suicide and investigate as to whether or not they were ever on singulair. Keep fighting. We'll get there! Kate K

5 months Singulair free,yesterday was Matts first day of high school,his first day of regular school in 2 years as he could not leave the house or cope with out panic and fear.7am he awoke by himself and got ready for school,the only thing i saw in his eyes was excitement,he left the house smiling.While he was gone i passed and worried waiting for the phone to ring in case he needed me ,watching the clock and wondering how his day was. he arrived home at 2 thirty still smiling,i asked him how his day was he said fine, i asked him what they did he said nothing ,lol all is good ,thank you thank you thank you

I have been reading all of these posts and have another question. I hope that someone can help. My daughter, 8 years old, has been on Singulair since she was 4. She is normally a very happy girl with a wonderful disposition. For the last year or so, she has been having trouble getting herself to sleep at night. She says that she hears things in her head such as ringing or "noises". A few hours before she knows it's bedtime, she cries and when we ask her why she's crying, she can't give us a reason. We initially thought that she was crying for no reason because she didn't want to go to sleep. I remember reading about the side effects of Singulair causing mood swings, etc., but her's are not violent mood swings. Just very emotional and has a hard time coming down from the "episode". I'm at a loss...I have not talked to her doctor yet about it, but have told her that we will make an appointment this week to discuss it with him. My husband suggested that maybe it sounded like she was having a panic attack or anxiety attack. I hate to label her as that at such a young age. My mind now goes back to the side effects of Singulair and maybe this is to blame. Any help or suggestions would be greatly appreciated. Thank you! Concerned Mom

My son, who just turned 14 this month, was on Singulair for over 2 years.
He was diagnosed with reactive airway disease and possibly Asthma--and prescribed this awful drug-even back in 2004. The doctor said how wonderful this med was and prevents any further attacks.. So, for 2 years-every night, he took this mood altering, destructive drug. He lost all interest in school, his athletics-soccer, skateboarding, biking..in fact became almost a vacant , very unhappy, child-had stomach aches, joint pains and reflux--why--I brought him to the doctor and Pediatric center so frequently--all they kept saying his --his asthma is better, much be other issues...Even after the March 2008 suicide--his doctor said-that is just an isolated incident-just monitor him--It is a good drug. Right, month by month his behavior escalated to wanting to die, no reason to go to school-he said he was stupid and a failure and why don't I understand there is no reason to his life. A usually happy fun-loving boy -my son- didn't want to live. Nothing made him happy-I started to believe what the doctors said--maybe something or someone at school (bully, pedophile??) caused this change. Terrible nightmares and vivid dreams...Until this past July, I asked him want to go to the library for some books or dvd's...he went ballistic-threw everything off his computer desk and tried to break his chair. He is not an aggressive boy but this behavior was becoming a daily issue. Along with everything flying off his table, was his bottle of Singulair pills. It then dawned on me..I have been poisoning my only son. The child I know and love and gave birth to returned within a few days--although I am worried sick about further asthma attacks --all the doctors can prescribe is a steroid drug-asthmex or Pulmicort.. I cannot understand nor comprehend why this drug is being prescribed for children and young adults. The guilt I live with is terrible as my son has lost 2 years of his life--
and thought there was something really wrong with him-At least we woke up---in time--how about some other parents..thinking it's just normal adolescent behavior for their child or their fault???

My son became soo aggressive 3 days after starting Singulair, that he was almost banned from soccer for life because of attacking another player on the field. It resembled what I had heard of 'roid rage'. When I questioned the doctor immediately, was told there was no connection. After months of the aggression, then came depression and self mutilation. My 15 yr old was secretly burning himself to 'punish' himself for things he done wrong or "disappointing" those around him. He now has permanent scars all over his arms from these burns. The depression took to drug abuse and my A student fell to an F student in 6 weeks. He completely lost his will to live and thrive. After 4 months of hell, the dr informed us that the FDA just warned physicians of this side effect. Im furious now that I read through the court documents and find that the drug company knew this all along. I know I am a luckier parent than some whose children committed suicide, but still wish that the FDA would get off their BUTTS and do something to take this drug off the market. I was told by a rep at the FDA that Merck will not take it off the shelf until they're made to because even if they had to pay parents millions for their child's suicide, they would still be pocketing more profit than our children's lives are worth in the court system. Not sure WHY we even HAVE an FDA, they won't do anything to protect us from these money hungry drug companies. A YEAR to do an 'INVESTIGATION" are you kidding me? If the CEO of Merck had to bury his child, it would come off the shelf THAT DAY.

I have asthma that was not controlled. I coughed and wheezed constantly. I had trouble eating, because even the food passing through the esophagus was enough to cause an attack. I was in and out of the emergency room for years, and the Ambulance folks knew to arrive with epinephrine when I'd call.

I started taking Singulair sometime around 1998. I haven't had any serious problems since then with asthma, and have had ZERO side effects.

Every drug has side effects for some people. For me, Claritin causes my heart to race. I can take that or that purple circurlar inhaler thing. I had a terrible reaction to that.

For ME, Singulair works. I am not sure it should be given to children if they are having severe problems. But it certainly should NOT be removed from the market...because people like me needed it to control their asthma.

I am a parent of a 14 year old son. He has been on many meds due to having migraines, adhd, seizures, and asthma. For 3 years his ADHD meds have been switched. Now Thanks to a friend she told me about singular side effects. OH MY GOD. it blows my mind reading this stuff. He has been on singular for 3 years and never once did I think all these problems were caused by that drug. Flipping out over the smallest things, arguing with us his parents, his friends, being mean to us and a real smartass, depression, and MAJOR attitude. Getting upset over nothing at all then crying for no reason What was his Dr. thinking? Needless to say, I took the singular while she was telling me this stuff about her own son, and threw them away, I will never allow my son to take that shit again. I hope in three days like all of you say, that my son will be that loving, caring, friendly person he use to be ! Singular free is how he will be!!

hi everyone my name is Katie, and my son has been on Sindulair for over 6 months now. I took him off 2 nights ago, the day I found this sight. I just cant believe how many families this medication has hurt. When my son was put on, I was never told anything about anything like this happening. I thought his behavior was due to the divorce and child custody things in his life that were going on. It did not cross my mind that it could ever be this medication. He does not take anything else at all.
Some of the things we have been dealing with are, panic attacks at night, bad dreams, aggressiveness, depression, anxiety! Fits that you would not believe. Crying all the time, very emotional. And the newest one, thinking everyone he loves is going to get killed. These are not things a 6 just turned 7 year old should be going through.
I got to thinking that I needed to get him some professional help, this is not normal! I decided to look up Singulair on the net, I did not find anything. I looked up Childrens depression, and angziat, still nothing fit. Then I found this site. Wow did it blow my mind. It fit and it felt right, if you are a mom, I think you know where I am coming from. When you know you just know! So I got him off the medication, and already I am seeing changes. The first night was not grate but better than it has been in a long time, the next day though, he woke up and smiled at me for the first time in way to long, he only had 2 meltdowns that day, when he was having at lest 2 in an hr before. So far so good, I just hope that It keeps going well for him.
Thank you for letting me tell my story!

I've been on Singulair for more than a few years now. I'm 43, with exercise and allergy induced asthma.....but mild. I also have VERY bad allergies. Talk about being allergic to EVERYTHING outside....that's me. I also suffer from migraines and depression. I've been on every antidepressant out there....still depressed. Now I know why...Singulair. I've tried tons of migraine meds....and I'm wondering if some of my side effects are really from Singulair. I'm moody, I don't care about other people's feelings like I used to, I snap at my kids like crazy,I cry at the drop of a hat....at stupid stuff. And now I'm thinking that my joint pain in my hips is from Singulair. But Singulair was my miracle drug for my asthma and a huge help to my Allegra D for my allergies. I'm asking the doc for an alturnative drug. As soon as I get it I'm off Singulair. ADIOS!

My 16 year old son took Singular for three days. Almost immediately after taking the first dose, he starting having increased blood pressure, rapid heart beat, tiredness, depression, thoughts of death, muscle soreness, tingling in his arms and legs, numbness, weird dreams (when he was actually able to sleep) and decreased appetite. He seriously thought that he was going crazy. It was not until I did some internet research that I finally linked all of his symptoms to this horrible drug. He stopped taking it on Friday of last week and each day since has been feeling better. He is not 100% back to normal yet, but each day seems to be better. It was a scary three day period while he was using this medication. Hopefully it will only take another day or two to get out of his system completely.

In response to Wewe's post, I've been wondering the same thing. Since taking my daughter off Singular almost 2 months ago, I'm seeing a different almost typical kid. Four years ago about 2 months after starting Singular my daughter was diagnosed with anxiety. As her condition got worse she was diagnosed with depression. We started to see OCD and tics so they were added as a diagnosis It was determined that it was related to strep infections so she was diagnosed with PANDAS. She was started on Zoloft and klonidine. The Zoloft made her worse. Her fears of hurting herself got so intrusive she was hospitalized. Her cholesterol was high too. The Zoloft was discontinued and Prozac was started. She's had therapy all 4 years. She also neede physical therapy due to muscle and joint pain. Now she's doing better, off Singular. Does she really have PANDAS, OCD? I don't know. She's still on Prozac, we just did a slight decrease this week. Is this medication the trigger for underlying conditions. Learned behaviors can be unlearned, but are there lasting physical effects? If a gene has been turned on, can it be turned off? I wish we knew the answers to help all of our kids.

Here is an example of the fact that the medical community recognizes that there are gene based drugs. Because Singulair is modeled to be a receptor antagonist to the cysLT1 receptor and the cysLT1 receptor is a gene, I'd say that Singulair should be described as a gene based drug. I don't really care how anybody wants to play with the definition. CysLT1 is a gene with known variations. Why isn't there just an "across the board" warning for all gene based drugs that unexpected side effects are possible???? And, that doctors should watch out for individual reactions.

WMJ. 2005 Aug;104(6):61-6.Links
Gene-based drug prescribing: clinical implications of the cytochrome P450 genes.Musana AK, Wilke RA.
Department of General Internal Medicine, Marshfield Clinic, WI, USA.

The Institute of Medicine recently mandated an increased effort to improve patient safety and reduce medical error. With the description of genetic polymorphisms in the drug metabolizing enzymes, the field of pharmacogenetics may improve medical care through a reduction in both therapeutic failure and adverse drug reaction. Investigators at the Marshfield Clinic in central Wisconsin are piloting the process of gene-based drug prescribing in a variety of contexts. This paper reviews the field of cytochrome P450 (CYP) genetics and explores factors that impact the utility of this information in clinical practice.

PMID: 16218319

Hi,
I wanted to post this link just to give some small consolation to our concerns about the lack of awareness THAT DOCTORS HAVE ABOUT SINGULAIR.This is a voluntary online informational site,that doctor's can join. It provides updated information on serious label changes and safety concerns on drugs.Most doctors at this point still get snail mail updates,in the paper shuffle a lot of information gets misplaced.The AMA would like to have all information come in online,eventually.The link is ******
read it and tell me if you think more can be done By the way my pediatricians office does not have online communication.Our life is forever changed because of that ! Information is playing a vital role in this drugs destructive path ,or the lack there of information.Again this is voluntary for the Doctors to sign up .In this modern day of communication how does important information not get where it is the most useful, I ask you?When drugs are making multi billion dollar profits,that would be an educated guess.I am doing another interview with CBS affiliate out of Boston on the 23rd of June,they contacted me.I hope it will reach more people who are still unaware of this drugs serious potential side effects.If any of you parents have some connection to media ,please use it to your best advantage to get this very important information out to the publicAlso so many of you ask how to help.Contact your local Senators and keep bothering them to reach out to the FDA to expedite this investigation. Make a pain in the butt out of yourself and be persistent.I will try to make reference to this site so your stories are heard. Dave and I are coming up on a year since our son passed on to our lord .Still fighting Kate and Dave M.

This testimony should help strengthen our case for warnings for Singulair.

Neurologist Sought Warning for Pfizer Drug
By JEREMY SINGER-VINE
June 20, 2008; Page B10

A British neurologist who analyzed effects of the drug Neurontin told a court hearing Thursday that he advised its maker -- now a unit of Pfizer Inc. -- to include a warning on the drug's label for potential side effects of depression and aggression, but his advice wasn't followed.

The University of London neurologist, Michael R. Trimble, was testifying at a hearing to decide whether civil cases brought against Pfizer alleging suicides linked to Neurontin can proceed. The hearing was jointly held by judges for U.S. District Court in Boston and a New York state court who are hearing similar cases. In various lawsuits consolidated in the federal court, plaintiffs allege more than 100 suicides were connected to Neurontin usage.

Dr. Trimble described what he said was a "plausible biological pathway" that could lead from the compound gabapentin -- the chemical name for Neurontin -- to suicidal behavior, hostility, and aggression. Dr. Trimble said that in 1995 and 1996, he was hired to write two confidential reports for Parke-Davis -- now a unit of Pfizer -- because the company "was concerned about psychosis in relation to their drug." Dr. Trimble said he was unable to find a link to psychosis, but noted effects of depression and aggression.

Lawyers for Pfizer argued at the hearing that the evidence linking the drug to suicidal side effects wasn't scientifically sound. Under cross-examination, they challenged his description of a pathway as a patchwork of studies that didn't prove a biological connection. Neurontin and generic forms of gabapentin are approved for treating epileptic convulsions, but have also been prescribed widely "off label" for other conditions.

In five of nine patient cases he analyzed in 1996, Dr. Trimble said he saw depression and aggression in patients who had no previous symptoms of the side effects, so he said he recommended to the company that the drug "should carry some kind of warning" for susceptible patients.

Thursday's proceedings were the initial phase of a hearing requested by Pfizer to challenge the opinions of the plaintiffs' experts. Under cross-examination and a subsequent examination by the plaintiffs' attorney, Dr. Trimble said the biological pathway between Pfizer's Neurontin and suicidal events were plausible and supported by a series of peer-reviewed neurology research.

Everybody here knows that I have been interested in trying to find out if Singulair (montelukast), which is a quinoline, ionizes and forms quinolinic acid under physiological conditions that lower blood pH. Some researchers have also mentioned that another montelukast metabolite that occurs is known to be a toxin. In other words, until someone can get blood tests that confirm what the toxic metabolic is, we are just guessing but I would bet that it is a good guess.

One of the strongest cases for that argument would be what happens to some people during sleep. There are some people whose CO2 levels rise. If the levels rise enough to cause change in pH to a more acid condition, then montelukast can possibly ionizes just enough to create minute amounts of neurotoxins that could cause bad dreams, hallucinations, sleep deprivation or a number of other neuro-psychiatric problems. Compound the effect of night after night of minute amounts of neurotoxins caused by CO2 and montelukast ionization then it would be easy to understand how depression and personality change results. There are other conditions that cause elevated CO2 levels and acidosis such as COPD.

If anyone has any data regarding their CO2 levels from sleep studies or other bloods tests, would you please send me a private message?

Last week, I had a PhD psychologist tell me that she is seeing a lot of patients come forward with Singulair stories, much like these. She's had at least 8 patients so far, and she has now added questions about allergy and Singulair to her patient intake procedures. Basically, they've all suffered from some sort of depression and personality change.