Doxycycline Hyclate and mood swings

I was put on 100mg 2x daily for a sinus infection and now I still have the infection plus other problems. I am a heavy eater and have not had a appetite for 3 days. I have some general stress and anxiety but this stuff has made it terrible. I have racing thoughts,panic attacks,confusion and mood swings. I will never take this crap again. I still have 4 days left. This stuff really is the DEVIL. Please do not take this drug its scary! Thank the Lord for this site. God bless. Jerry.

I've only been on Doxycycline Hyclate for 2 weeks - I am supposed to take it for 2 months to clear up my acne. The first side effect I experienced was the nausea/vomiting. I HAVE to eat something before I take it or it makes me throw up. I was sensitive to the sun, but the thing that was the most bothersome was the tingling in my feet & hands. When water touched them, they would tingle as if they were asleep. It was a very weird feeling. The worst side effect for me, though, are my mood swings. I get so angry I feel almost like I'm going to explode. I can't just drop it like I usually do - I just keep fighting & yelling - which is not like me. I've been saying things I don't mean & lashing out over stupid small things. I feel almost as if I'm going crazy. This is just the first 2 weeks, after reading this board, I'm wondering if it's even worth continuing. Supposedly, when this is prescribed for acne, most cases come back after you stop taking the pill. If it's going to come back anyways, I'd rather not put myself through this for 2 months...

I'm taking Doxycycline 100mg 5x/day. Started a little over 2 weeks ago for Chronic Lyme. I have a 4 month course to complete.
In the past 14 years after that tick got me I was the living dead, those with Chronic Lyme know what I mean. I have virtually the same side effects as everyone else here and wonder if it even matters how much you take a day. A lot of you have the same doses (100mg 2x/day) and the same degree of side effects as I do. My side effects are headaches or a pain in my right temple whenever I cough, severe itching EVERYWHERE, blisters on my hands from itching, burns on my skin wherever the sun shines on me (I live in Florida), vomiting daily some days worse than others, mood swings, crying for nothing, nausea almost constantly, gassy (both ends), I have a bladder infection that started 2 days ago that after reading this can be attributed to the Doxy, asthma symptoms are getting out of hand, I also have this odd swelling/pain over my liver/gall bladder area that's been coming and going, ears ring, noise bothers me and actually starts a headache, diarrhea the first week and constipation the second week, skin feels tight and there's noticeable swelling all over.

With that said I want to say that yes this is not one of the more pleasant drugs to be on however in my case if I don't get these bugs out of me I am going to die so would rather deal with side effects knowing these bugs are being killed and I will be off them someday unlike the Lyme I will have for eternity. Lyme people and other chronically ill people on these meds say this is called "herxing" and this comes and goes also. You feel really bad and then you feel good, then bad and then good again and so on. I started out on this drug keeping in mind that any sikness/side effect was telling me those bugs are dying so in a sense I almost welcome them.

Good luck everyone:)

I was on Minocycline (a cousin to Doxycycline Hyclate) for years. I’m not sure how long exactly as I didn’t write down the date that I started, but I believe I have been on it around 3-4+ years. Well I went to a dermatologist and he instantly looked at the outer area of my arms (just above the elbow) and recognized I am suffering from skin discoloration, and prescribed Doxycycline, and told me to stop taking Minocycline right away. I also have this blue-gray skin discoloration on my back near my shoulder blades. I took my Minocycline for the next two weeks till the Doxycycline came in then stopped the minocycline, and started Doxycycline on Sunday. I take a 100mg pill twice daily with a meal, and thus far have had no issues. Keep in mind that I have been on Minocycline for the past 4 years or so and maybe I’ve been suffering similar side effects on that drug, thus I would be unable to see the difference with Minocycline’s cousin Doxycycline. I am pretty sure the first year or two that I was on Minocycline I was depressed (other things in life may have contributed to this depression, but now that I see all of these people saying they have had mood swings, I must state that I have had many more mood swings in recent years then I ever remember before being on these meds). I have also been extremely sleepy the past few years. I used to NEVER be able to fall asleep in public, but (I believe about the same time I started Minocycline) I gained the ability to sleep anywhere. Now I mean, anywhere. I can sleep even after I get anywhere between 6 and 14 hours of sleep. I have had approx 7-9 hours of sleep on average for the past 6 months, yet am always tired. I can’t remember the last time I haven’t been sleepy, and have had many doctor visits to attempt to discover the reason for this, but hadn’t read the side effects of Minocycline. I’ve still been pretty sleepy since Sunday, but I’ll hope that this Doxycycline isn’t as bad. Anyone else have a similar issue, where you used to be awake, but now you are always sleepy (wake up in the mornings a bit dizzy and confused), and have a hard time concentrating on one thing at a time?

Wow. I just have to say AMEN! I have been feeling so, so low since starting Doxy. My derma wants me on 200 mg a day for the next 6 weeks! I don't think I can do it - it's completely thrown my body out of whack. And my spirit is just so low. My God what's in this stuff? It has made dramatic improvment in my acne though - so it's tempting to stay on it and milk the benefits for as long as I can. Interesting I'm experiencing mood swings - bouts of silliness and then just a quiet low feeling that goes deep. I'm a pretty stable person mood wise. So glad I typed "Doxy and depression" into google!

Interesting, my accupuncturist says healthy digestive track promotes clearer skin and a happier outlook on life. THis stuff does exactly the opposite to my stomach. This stuff is crap!

It is amazing how many people have experienced tightness in the chest, anxiety, and mood swings with this drug. None of this was mentioned by my doctor when he prescribed doxycyline for my adult acne. And I asked him about all of the side effects, as I was very wary about taking the drug to begin with. Until reading this forum, I thought I was going a little crazy. A generally happy, worry-free person, I experienced anxiety, sleeplessness, tightness in the chest, and trouble breathing. I recently quit taking this medication because I believe it was causing my skin to itch like mad. I already feel better mentally and physically. I will look for another solution for my acne and never again take doxycyline. It is very bad.

Upper GI distress-bloating-loss of appetite-chest pains, very likely stomach related, not heart. Esophageal burning, never any heartburn before. Mood swings, definitely not positive mood! Taking for MRSA sinuses, contracted at workplace after having extensive sinus surgery two years ago. Have taken several rounds doxyclycline, infection always comes back after finishing med two weeks prior. Thank you for your interest.