Brain cells symptoms and conditions

This testimony should help strengthen our case for warnings for Singulair.

Neurologist Sought Warning for Pfizer Drug
By JEREMY SINGER-VINE
June 20, 2008; Page B10

A British neurologist who analyzed effects of the drug Neurontin told a court hearing Thursday that he advised its maker -- now a unit of Pfizer Inc. -- to include a warning on the drug's label for potential side effects of depression and aggression, but his advice wasn't followed.

The University of London neurologist, Michael R. Trimble, was testifying at a hearing to decide whether civil cases brought against Pfizer alleging suicides linked to Neurontin can proceed. The hearing was jointly held by judges for U.S. District Court in Boston and a New York state court who are hearing similar cases. In various lawsuits consolidated in the federal court, plaintiffs allege more than 100 suicides were connected to Neurontin usage.

Dr. Trimble described what he said was a "plausible biological pathway" that could lead from the compound gabapentin -- the chemical name for Neurontin -- to suicidal behavior, hostility, and aggression. Dr. Trimble said that in 1995 and 1996, he was hired to write two confidential reports for Parke-Davis -- now a unit of Pfizer -- because the company "was concerned about psychosis in relation to their drug." Dr. Trimble said he was unable to find a link to psychosis, but noted effects of depression and aggression.

Lawyers for Pfizer argued at the hearing that the evidence linking the drug to suicidal side effects wasn't scientifically sound. Under cross-examination, they challenged his description of a pathway as a patchwork of studies that didn't prove a biological connection. Neurontin and generic forms of gabapentin are approved for treating epileptic convulsions, but have also been prescribed widely "off label" for other conditions.

In five of nine patient cases he analyzed in 1996, Dr. Trimble said he saw depression and aggression in patients who had no previous symptoms of the side effects, so he said he recommended to the company that the drug "should carry some kind of warning" for susceptible patients.

Thursday's proceedings were the initial phase of a hearing requested by Pfizer to challenge the opinions of the plaintiffs' experts. Under cross-examination and a subsequent examination by the plaintiffs' attorney, Dr. Trimble said the biological pathway between Pfizer's Neurontin and suicidal events were plausible and supported by a series of peer-reviewed neurology research.

I have waited long enough to tell my story. I am a 29 yr old single mother of 3. I started YAZ in Feb of 2008. I took it for 11 days. ELEVEN DAYS. It was about 4 days in that the headaches started. I couldn't stand light, I wore hoodies and sunglasses. I was nauseated. Saw double, black spots. Motion sickness.I could barely make it to work. I was out of control. I did not have control over my mind. I was crazy. My friend almost took me to the hospital to have me committed. There is no history of this in me or my family. The headaches would last from the time I woke up til the time I would go to sleep. Painkillers was the only thing that would keep me asleep through the pain. My dr immediately stop the the pills. I saw an eye doctor and they found nothing. They ordered an MRI. They found T2 Foci scattered throughout my brain. VERY unusual in someone my age. What that is, is my protective covering of my brain cells had been damaged there were gaps in its covering. I soon developed a stutter and a slur in my speech. The pain then moved throughout my whole body. They said fibromyalga and daily migraines. I'm now on topamax daily which gives me breaks in my headaches. I still get them daily. I still have pain in my body daily and I'm on painkillers daily. I have found a new dr who is wonderful. Who has recently taken blood. Who thinks that maybe it could be lupus. So I started researching Lupus...my symptoms and rashes match up. There is also a DRUG INDUCED LUPUS. and ORAL CONTRACEPTIVES is a KNOWN drug that can cause this!!! BUT IS THAT ON THE LABEL???? NOOOOOOOO!!! I was perfectly healthy before yaz, in kick boxing and now I walk and have the memory of a 60 yr old and my brain is permanently damaged. I have another MRI coming up to find out if there is more damage and I will find out the results of the blood work to find out what is wrong with me...but I blame all of this on YAZ and I hold them responsible. I SAY CLASS ACTION LAW SUIT....just have to find a firm with big enough BALLS to do it!!!

lamictal controls seizures if you take it at the right time. i am on 200 at night and 200 in the morning plus epilim. sometimes i just sit and cry wen im trying to concentrate on reading books i have to study or trying to remember work i learnt at school which has left my brain. im failing school not matter how hard i try, i study all the time then the next day i have forgotten it. im so young and i havnt even started my future yet and i may have screwed it already. failing exams because i forgot wat i learnt the night before hurts so bad. its hard to say "hey everyone the reason i failed is because lamictal screws my memory" i know thats what it is. i was extremely intelligent before i started taking it, but now im a failure. i guess deep inside i know really im not a failure, but lamictal makes me one. : ( p.s add a constant hand tremor and sudden jerking movements every now and then.