Cotrim Information

What's inside Cotrim

Cotrim in the News

Mercedes Sprinter is child’s play for party organisers - Transport News Network
CoTrim of Salisbury added a second row of seats, an integrated bulkhead and luxury trim, including walnut veneer in the passenger compartment and ...
Wed Feb 06 10:49:59 -0500 2008

Mercedes Sprinter is child’s play for party organisers - Transport News Network
CoTrim of Salisbury added a second row of seats, an integrated bulkhead and luxury trim, including walnut veneer in the passenger compartment and ...
Wed Feb 06 10:49:59 -0500 2008

EU leaders sign bloc's new treaty - Fort Worth Star Telegram
By BARRY HATTON AP Writer AP Photo/Lusa, Antonio Cotrim Portuguese Prime-Minister Jose Socrates speaks, prior to signing the EU's Treaty of Lisbon during a ...
Thu Dec 13 12:27:25 -0500 2007

Cotrim Chemical Information

sulfamethoxazole - A broad-spectrum, short-acting sulfanilamide and a synthetic analog of para-aminobenzoic acid (PABA) with antibacterial property. Sulfamethoxazole competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.

trimethoprim - A synthetic derivative of trimethoxybenzyl-pyrimidine with antibacterial and antiprotozoal properties. As a pyrimidine inhibitor of bacterial dihydrofolate reductase, trimethoprim binds tightly to the bacterial enzyme, blocking the production of tetrahydrofolic acid from dihydrofolic acid. The antibacterial activity of this agent is potentiated by sulfonamides. (NCI04)