Benazepril-Hydrochlorothiazide Information

What's inside Benazepril-Hydrochlorothiazide

Recent Benazepril-Hydrochlorothiazide Side Effects

Posted by gllipsey 8 months ago
I have been taking this medication for about a week now and notice that my eye jumps all during the day and when i try to c...

Posted by merrimari about 1 year ago
I was recently taken off of 10mg of Lisinopril and put on 20mg/25mg of Benazepril/HCTZ. Is this medication the same as Lisino...

Benazepril-Hydrochlorothiazide Chemical Information

benazepril hydrochloride - Thy hydrochloride salt of a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril hydrochloride is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Benazepril hydrochloride also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

hydrochlorothiazide - The hydrogenated derivative of chlorothiazide, a thiazide diuretic with antihypertensive and anti-urolithic effects. This agent binds to the electroneutral Na-K-Cl cotransporter (NKCC) and thereby impairs Na+, K+ and Cl- reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in urinary excretion of sodium, chloride, potassium, bicarbonate and water subsequently reducing plasma and extracellular fluid volume leading to a reduction in blood pressure. Hydrochlorothiazide also decreases urinary calcium and uric acid excretion by direct action on the distal tubule.